The aim of this study was to analyse the modulatory role of endothelin-1 and vasopressin in sympathetic vasoconstriction, and whether there are gender differences in this modulatory role. Electrical field stimulation (4Hz, 0.2ms pulse duration at supramaximal voltage of 70V, for 1s), applied to isolated segments from rat tail arteries, produced a contraction that was lower in the vascular segments from female than in those from male rats. This arterial contraction was potentiated in a concentration-dependent way by endothelin-1 (10-10–3×10-9mol/l) and vasopressin (10-12–10-10mol/l), and the increment produced by endothelin-1 was similar in the arteries of both, whereas the increment induced by vasopressin was higher in the arteries from male than in those from female rats. These results suggest that endothelin-1 and vasopressin potentiate the vasoconstriction to sympathetic stimulation, and this potentiating effect of vasopressin may be higher, whereas that of endothelin-1 may be similar, in males than in females.
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September 2002
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September 01 2002
Potentiation by endothelin-1 and vasopressin of sympathetic vasoconstriction in male and female rats
Nuria FERNÁNDEZ;
Nuria FERNÁNDEZ
1Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma, Arzobispo Morcillo 2, 28029 Madrid, Spain
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Elena SANZ;
Elena SANZ
1Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma, Arzobispo Morcillo 2, 28029 Madrid, Spain
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Luis MONGE;
Luis MONGE
1Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma, Arzobispo Morcillo 2, 28029 Madrid, Spain
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María Angeles MARTÍNEZ;
María Angeles MARTÍNEZ
1Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma, Arzobispo Morcillo 2, 28029 Madrid, Spain
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Godofredo DIÉGUEZ;
Godofredo DIÉGUEZ
1Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma, Arzobispo Morcillo 2, 28029 Madrid, Spain
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Angel Luis GARCÍA-VILLALÓN
1Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma, Arzobispo Morcillo 2, 28029 Madrid, Spain
Dr A.L. García-Villalón (e-mail [email protected]).
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Publisher: Portland Press Ltd
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2002 The Biochemical Society and the Medical Research Society
2002
Clin Sci (Lond) (2002) 103 (s2002): 158S–161S.
Citation
Nuria FERNÁNDEZ, Elena SANZ, Luis MONGE, María Angeles MARTÍNEZ, Godofredo DIÉGUEZ, Angel Luis GARCÍA-VILLALÓN; Potentiation by endothelin-1 and vasopressin of sympathetic vasoconstriction in male and female rats. Clin Sci (Lond) 1 September 2002; 103 (s2002): 158S–161S. doi: https://doi.org/10.1042/CS103S158S
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