The coronary effects of endothelin-1 (ET-1) during acute hypertension were examined in anesthetized goats, where the left circumflex coronary artery flow was electromagnetically measured and hypertension was induced by constriction of the thoracic aorta. In six non-treated goats, aortic constriction increased arterial pressure (mean arterial pressure = 128±5mmHg) and coronary flow (by 34%) without changing coronary vascular conductance. In this case, ET-1 (0.01–0.3nmol) when injected intracoronarily, decreased coronary vascular conductance, which was similar in hypertension and in normotension. In eight NG-nitro-L-arginine methyl ester-treated goats, aortic constriction increased arterial pressure (mean arterial pressure = 131±5mmHg) and coronary flow (by 26%) and decreased coronary vascular conductance (by 17%). In this case, ET-1 (0.01–0.3nmol) also decreased coronary vascular conductance, which was similar in NG-nitro-L-arginine methyl ester-treated hypertension that observed in normotension. Therefore, acute hypertension attenuates the coronary vasoconstriction caused by ET-1, and this attenuation might be related to mechanisms other than changes in NO release.
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September 2002
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Conference Article|
September 01 2002
Coronary effects of endothelin-1 during acute hypertension in anaesthetized goats
Nuria FERNÁNDEZ;
Nuria FERNÁNDEZ
1Departamento de Fisiología, Facultad de Medicina, Universidad Autónma, Arzobispo Morcillo 2, 28029 Madrid, Spain
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María ANGELES MARTÍNEZ;
María ANGELES MARTÍNEZ
1Departamento de Fisiología, Facultad de Medicina, Universidad Autónma, Arzobispo Morcillo 2, 28029 Madrid, Spain
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Angel Luis GARCÍA-VILLALÓN;
Angel Luis GARCÍA-VILLALÓN
1Departamento de Fisiología, Facultad de Medicina, Universidad Autónma, Arzobispo Morcillo 2, 28029 Madrid, Spain
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Luis MONGE;
Luis MONGE
1Departamento de Fisiología, Facultad de Medicina, Universidad Autónma, Arzobispo Morcillo 2, 28029 Madrid, Spain
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Godofredo DIÉGUEZ
1Departamento de Fisiología, Facultad de Medicina, Universidad Autónma, Arzobispo Morcillo 2, 28029 Madrid, Spain
Dr G. Diéguez ([email protected]).
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Publisher: Portland Press Ltd
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2002 The Biochemical Society and the Medical Research Society
2002
Clin Sci (Lond) (2002) 103 (s2002): 376S–379S.
Citation
Nuria FERNÁNDEZ, María ANGELES MARTÍNEZ, Angel Luis GARCÍA-VILLALÓN, Luis MONGE, Godofredo DIÉGUEZ; Coronary effects of endothelin-1 during acute hypertension in anaesthetized goats. Clin Sci (Lond) 1 September 2002; 103 (s2002): 376S–379S. doi: https://doi.org/10.1042/CS103S376S
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