Plasma endothelin (ET)-1 concentrations have been shown to be elevated in patients receiving calcineurin-inhibitors (CI). We investigated urinary and plasma ET-1 (uET-1, pET-1), BigET-1 (uBigET-1, pBigET-1) concentrations, and plasma soluble endothelin-converting enzyme (ECE) concentrations in 381 adult caucasian kidney allograft recipients with graft survival of more than 2 years from the outpatients department of our clinic. Blood and urine probes were always drawn immediately before morning dosage of immunosuppressants. Mean of urinary protein excretion (meanProt) and mean of serum creatinine (meanCrea) were calculated from all available measurements in the most recent year. uET-1 and uBigET-1 were adjusted for urinary protein excretion by calculating uET-1/meanProt and uBigET-1/meanProt. Patients (n = 310) were on a cyclosporine A or FK506 (CI-group) based immunosuppression protocol, and 71 patients were immunosuppressed without use of CI (nonCI group). Time since transplantation was similar in both groups (mean±S.D.; CI-group: 7.55±2.50; nonCI-group: 7.74±3.06 years, P = 0.240) as well as meanCrea (mean±S.D.; CI-group: 1.97±1.34; nonCI-group: 1.77±1.29mg/dl, P = 0.326). pET-1 was significantly higher in the CI-group, compared with nonCI (mean±S.D.; 0.87±1.4 versus 0.56±0.76fmol/ml, P = 0.011). pBigET-1 was similar (mean±S.D.; 0.85±1.41 versus 0.70±1.21fmol/ml, P = 0.33). ECE concentrations were higher in the CI group (mean±S.D.; 14.30±18.02 versus 9.23±7.42ng/ml, P = 0.001). uET-1/meanProt and uBigET-1/meanProt concentration were similar in the CI-group compared with the nonCI-group (mean±S.D.; uET-1/meanProt: 15±24 versus 21±40pmol/g, P = 0.139; uBigET-1/meanProt: 34±55 versus 19±23pmol/g, P = 0.248). pET-1 elevation in patients receiving CI might be more likely to be due to elevated conversion of pBig-ET-1 by more ECE, and not to higher concentrations of pBigET-1.
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September 2002
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Conference Article|
September 01 2002
Interaction of the endothelin system and calcineurin inhibitors after kidney transplantation
Torsten SLOWINSKI;
Torsten SLOWINSKI
*Department of Nephrology, University Hospital Charité, Humboldt University of Berlin, D-10098 Berlin, Germany
†Institute of Molecular Biology and Biochemstry, Free University of Berlin, D-14195 Berlin, Germany
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Thomas SUBKOWSKI;
Thomas SUBKOWSKI
‡Department of Pharmaceutical Research, BASF AG, D-67008 Ludwigshafen, Germany
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Petra DIEHR;
Petra DIEHR
*Department of Nephrology, University Hospital Charité, Humboldt University of Berlin, D-10098 Berlin, Germany
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Daniela BACHERT;
Daniela BACHERT
*Department of Nephrology, University Hospital Charité, Humboldt University of Berlin, D-10098 Berlin, Germany
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Lutz FRITSCHE;
Lutz FRITSCHE
*Department of Nephrology, University Hospital Charité, Humboldt University of Berlin, D-10098 Berlin, Germany
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Hans.-H. NEUMAYER;
Hans.-H. NEUMAYER
*Department of Nephrology, University Hospital Charité, Humboldt University of Berlin, D-10098 Berlin, Germany
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Berthold HOCHER
*Department of Nephrology, University Hospital Charité, Humboldt University of Berlin, D-10098 Berlin, Germany
†Institute of Molecular Biology and Biochemstry, Free University of Berlin, D-14195 Berlin, Germany
Dr B. Hocher, Department of Nephrology, University Hospital Charité, Humboldt University of Berlin, Schumannstrasse 20-21, 10098 Berlin, Germany (e-mail [email protected]).
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Publisher: Portland Press Ltd
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2002 The Biochemical Society and the Medical Research Society
2002
Clin Sci (Lond) (2002) 103 (s2002): 396S–398S.
Citation
Torsten SLOWINSKI, Thomas SUBKOWSKI, Petra DIEHR, Daniela BACHERT, Lutz FRITSCHE, Hans.-H. NEUMAYER, Berthold HOCHER; Interaction of the endothelin system and calcineurin inhibitors after kidney transplantation. Clin Sci (Lond) 1 September 2002; 103 (s2002): 396S–398S. doi: https://doi.org/10.1042/CS103S396S
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