Secondary complications of diabetes mellitus often involve gastrointestinal dysfunction. In the experimental Goto Kakizaki rat, a model of Type II diabetes, hyperglycaemia and reduced glucose clearance is associated with elevated plasma endothelin (ET)-1 levels and selective decreases in nitric oxide synthase in circular muscle, longitudinal muscle and neuronal elements of the gastrointestinal tract. Functionally, this is accompanied by decreased nitrergic relaxatory responses of jejunal longitudinal muscle to tetrodotoxin-sensitive electrical field stimulation. Long-term treatment with a selective ET A-type receptor antagonist, markedly reduced hyperglycaemia and restored plasma glucose clearance rates towards normal. This was associated with a restoration of NG-nitro-L-arginine methyl ester-sensitive relaxatory responses of jejunal longitudinal muscle to electrical field stimulation. The results indicate that beneficial effects of ETA receptor blockade on gastrointestinal function may result from an improvement in insulin sensitivity with concomitant reduction of the severity of hyperglycaemia. ETA receptor blockade may represent a new therapeutic principle for improving glucose tolerance in Type II diabetes and could be beneficial in alleviating or preventing hyperglycaemia-related secondary complications in this condition.
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September 2002
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Conference Article|
September 01 2002
Endothelin A-receptor blockade in experimental diabetes improves glucose balance and gastrointestinal function
Bruno BALSIGER;
Bruno BALSIGER
*Clinical Pharmacology, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland
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Andreas RICKENBACHER;
Andreas RICKENBACHER
*Clinical Pharmacology, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland
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Penelope Jane BODEN;
Penelope Jane BODEN
†Department of Clinical Research, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland
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Erwin BIECKER;
Erwin BIECKER
*Clinical Pharmacology, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland
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Janice TSUI;
Janice TSUI
‡The Royal Free and University College Medical School, University College London, Royal Free Campus, Pond Street, London NW3 2QG, U.K.
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Michael DASHWOOD;
Michael DASHWOOD
‡The Royal Free and University College Medical School, University College London, Royal Free Campus, Pond Street, London NW3 2QG, U.K.
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Jürg REICHEN;
Jürg REICHEN
*Clinical Pharmacology, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland
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Sidney George SHAW
†Department of Clinical Research, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland
Dr S.G. Shaw (e-mail [email protected]).
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Publisher: Portland Press Ltd
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2002 The Biochemical Society and the Medical Research Society
2002
Clin Sci (Lond) (2002) 103 (s2002): 430S–433S.
Citation
Bruno BALSIGER, Andreas RICKENBACHER, Penelope Jane BODEN, Erwin BIECKER, Janice TSUI, Michael DASHWOOD, Jürg REICHEN, Sidney George SHAW; Endothelin A-receptor blockade in experimental diabetes improves glucose balance and gastrointestinal function. Clin Sci (Lond) 1 September 2002; 103 (s2002): 430S–433S. doi: https://doi.org/10.1042/CS103S430S
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