A Hydrophobic Cavity in α1-Antitrypsin Is a Target for Rational Drug Design to Prevent Polymerisation and Disease

Parfrey, Helen; Mahadeva, Ravi; Zhou, Aiwu; Dafforn, Timothy R; Lomas, David A

doi:10.1042/cs103055Pb

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Conference Abstract| July 01 2002

A Hydrophobic Cavity in α₁-Antitrypsin Is a Target for Rational Drug Design to Prevent Polymerisation and Disease

Helen Parfrey;

Helen Parfrey

1Respiratory Medicine Unit, Department of Medicine, Cambridge Institute for Medical Research, Hills Road, Cambridge. CB2 2XY.

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Ravi Mahadeva;

Ravi Mahadeva

1Respiratory Medicine Unit, Department of Medicine, Cambridge Institute for Medical Research, Hills Road, Cambridge. CB2 2XY.

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Aiwu Zhou;

Aiwu Zhou

1Respiratory Medicine Unit, Department of Medicine, Cambridge Institute for Medical Research, Hills Road, Cambridge. CB2 2XY.

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Timothy R Dafforn;

Timothy R Dafforn

1Respiratory Medicine Unit, Department of Medicine, Cambridge Institute for Medical Research, Hills Road, Cambridge. CB2 2XY.

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David A Lomas

1Respiratory Medicine Unit, Department of Medicine, Cambridge Institute for Medical Research, Hills Road, Cambridge. CB2 2XY.

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Author and article information

Publisher: Portland Press Ltd

Online ISSN: 1470-8736

Print ISSN: 0143-5221

2002

Clin Sci (Lond) (2002) 103 (s47): 55P.

https://doi.org/10.1042/cs103055Pb

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A Hydrophobic Cavity in α₁-Antitrypsin Is a Target for Rational Drug Design to Prevent Polymerisation and Disease