The effects of gas mixtures comprising supplementary 3% carbon dioxide, 35% oxygen or a combination of 3% CO2 plus 35% O2 in ambient air have been compared on arterial blood gases, peripheral and cerebral oxygenation and middle cerebral artery velocity (MCAV) at 150m and on acute exposure to 3459m in 12 healthy subjects. Breathing 3% CO2 or 35% O2 increased arterial blood oxygen at both altitudes, and the CO2/O2 combination resulted in the most marked rise. MCAV increased on ascent to 3459m, increasing further with 3% CO2 and decreasing with 35% O2 at both altitudes. The CO2/O2 combination resulted in an increase in MCAV at 150m, but not at 3549m. Cerebral regional oxygenation fell on ascent to 3459m. Breathing 3% CO2 or 35% O2 increased cerebral oxygenation at both altitudes, and the CO2/O2 combination resulted in the greatest rise at both altitudes. The combination also resulted in significant rises in cutaneous and muscle oxygenation at 3459m. The key role of carbon dioxide in oxygenation at altitude is confirmed, and the importance of this gas for tissue oxygenation is demonstrated.
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January 28 2003
Effects of breathing air containing 3% carbon dioxide, 35% oxygen or a mixture of 3% carbon dioxide/35% oxygen on cerebral and peripheral oxygenation at 150 m and 3459 m
C.H.E. IMRAY;
*University Hospitals Coventry and Warwickshire NHS Trust, Department of Vascular Surgery, Clifford Bridge Road, Walsgrave, Coventry CV2 2DX, U.K.
Correspondence: Mr Chris Imray (e-mail [email protected]).
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S. WALSH;
S. WALSH
†Immunodiagnostic Research Laboratory, The Medical School, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, U.K.
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T. CLARKE;
T. CLARKE
†Immunodiagnostic Research Laboratory, The Medical School, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, U.K.
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C. TIIVAS;
C. TIIVAS
*University Hospitals Coventry and Warwickshire NHS Trust, Department of Vascular Surgery, Clifford Bridge Road, Walsgrave, Coventry CV2 2DX, U.K.
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H. HOAR;
H. HOAR
†Immunodiagnostic Research Laboratory, The Medical School, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, U.K.
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T.C. HARVEY;
T.C. HARVEY
‡Department of Medicine, Manor Hospital, Walsall, U.K.
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C.W.M. CHAN;
C.W.M. CHAN
*University Hospitals Coventry and Warwickshire NHS Trust, Department of Vascular Surgery, Clifford Bridge Road, Walsgrave, Coventry CV2 2DX, U.K.
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P.J.G. FORSTER;
P.J.G. FORSTER
§Department of Medicine, James Paget Hospital, Great Yarmouth, Norfolk, U.K.
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A.R. BRADWELL;
A.R. BRADWELL
†Immunodiagnostic Research Laboratory, The Medical School, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, U.K.
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A.D. WRIGHT
A.D. WRIGHT
‡Department of Medicine, Manor Hospital, Walsall, U.K.
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Publisher: Portland Press Ltd
Received:
April 17 2002
Revision Received:
September 10 2002
Accepted:
November 26 2002
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2003
2003
Clin Sci (Lond) (2003) 104 (3): 203–210.
Article history
Received:
April 17 2002
Revision Received:
September 10 2002
Accepted:
November 26 2002
Citation
C.H.E. IMRAY, S. WALSH, T. CLARKE, C. TIIVAS, H. HOAR, T.C. HARVEY, C.W.M. CHAN, P.J.G. FORSTER, A.R. BRADWELL, A.D. WRIGHT; Effects of breathing air containing 3% carbon dioxide, 35% oxygen or a mixture of 3% carbon dioxide/35% oxygen on cerebral and peripheral oxygenation at 150 m and 3459 m. Clin Sci (Lond) 1 March 2003; 104 (3): 203–210. doi: https://doi.org/10.1042/cs1040203
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