The present study was designed to test the hypothesis that enhanced intracellular calcium signalling and increased sodium/lithium countertransport (Na+/Li+ CT) activity may be associated with coronary heart disease (CHD) in non-diabetic patients with essential hypertension. Platelet-activating factor (PAF)-evoked rises in the intracellular calcium concentration ([Ca2+]i) were measured in Epstein–Barr-virus-immortalized lymphoblasts from 62 hypertensive patients with CHD and 34 patients without CHD. Na+/Li+ CT activity was assessed in erythrocytes from 80 hypertensive patients with CHD and 46 patients without CHD. Baseline values of unstimulated and PAF-stimulated [Ca2+]i were not significantly different between hypertensive subjects with (baseline, 126±5nmol/l; stimulated, 550±43nmol/l) and without (baseline, 125±5nmol/l; stimulated, 654±105nmol/l) CHD. Similarly, Na+/Li+ CT activity was not significantly different between the two groups (patients with CHD, 219±8µmol·l-1·h-1; patients without CHD, 234±10µmol·l-1·h-1). We conclude that intracellular signal transduction, as indicated by PAF-induced rises in [Ca2+]i and Na+/Li+ CT activity, is not associated with an increased risk of CHD in non-diabetic patients with essential hypertension.
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March 2003
Research Article|
February 17 2003
Sodium/lithium countertransport and intracellular calcium concentration in patients with essential hypertension and coronary heart disease
Sybille GRUSKA;
*Department A of Internal Medicine, Ernst Moritz Arndt University Greifswald, Loefflerstrasse 23a, D-17487 Greifswald, Germany
Correspondence: Dr Sybille Gruska (e-mail gruska@uni-greifswald.de).
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Ingo JENDRAL;
Ingo JENDRAL
*Department A of Internal Medicine, Ernst Moritz Arndt University Greifswald, Loefflerstrasse 23a, D-17487 Greifswald, Germany
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Rainer RETTIG;
Rainer RETTIG
†Department of Physiology, Ernst Moritz Arndt University Greifswald, Greifswalder Strass 11C, D-17495 Karlsburg, Germany
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Günter KRAATZ
Günter KRAATZ
*Department A of Internal Medicine, Ernst Moritz Arndt University Greifswald, Loefflerstrasse 23a, D-17487 Greifswald, Germany
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Clin Sci (Lond) (2003) 104 (3): 323–327.
Article history
Received:
September 27 2002
Revision Received:
November 29 2002
Accepted:
January 02 2003
Citation
Sybille GRUSKA, Ingo JENDRAL, Rainer RETTIG, Günter KRAATZ; Sodium/lithium countertransport and intracellular calcium concentration in patients with essential hypertension and coronary heart disease. Clin Sci (Lond) 1 March 2003; 104 (3): 323–327. doi: https://doi.org/10.1042/cs1040323
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