Targeting a Surface Cavity of α1-Antitrypsin to Prevent Conformational Disease

Parfrey, Helen; Ravenhill, Neil; Mahadeva, Ravi; Zhou, Aiwu; Dafforn, Timothy R.; Foreman, Richard C.; Lomas, David A.

doi:10.1042/cs104057P

Targeting a Surface Cavity of α₁-Antitrypsin to Prevent Conformational Disease

Helen Parfrey;

Helen Parfrey

¹ Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge. CB2 2XY, U.K.

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Neil Ravenhill;

Neil Ravenhill

² Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton. S09 3TU. U.K.

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Ravi Mahadeva;

Ravi Mahadeva

¹ Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge. CB2 2XY, U.K.

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Aiwu Zhou;

Aiwu Zhou

¹ Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge. CB2 2XY, U.K.

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Timothy R. Dafforn;

Timothy R. Dafforn

¹ Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge. CB2 2XY, U.K.

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Richard C. Foreman;

Richard C. Foreman

² Department of Physiology and Pharmacology, University of Southampton, Bassett Crescent East, Southampton. S09 3TU. U.K.

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David A. Lomas

¹ Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge. CB2 2XY, U.K.

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Targeting a Surface Cavity of α₁-Antitrypsin to Prevent Conformational Disease