The functions of natural killer (NK) cells are controlled by an abundance of activating and inhibitory receptors. Many of these interact with MHC class I molecules. The MHC system also interacts with cytotoxic T-lymphocytes and has been shown to comprise a rapidly evolving family of molecules. This challenges the functional relationship of NK cell receptors with their ligands. Although individual receptors have become subject to species-specific expansions over evolutionary time, the main themes of the NK cell interaction with MHC class I have been preserved. This review details the interaction of NK cell receptors with MHC class I and discusses their unexpectedly rapid evolution.
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Review Article| August 01 2003
MHC class I receptors on natural killer cells: on with the old and in with the new
Salim I. KHAKOO;
1Division of Infection Inflammation and Repair, School of Medicine, University of Southampton, Mailpoint 811, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, U.K.
Correspondence: Dr S. I. Khakoo (e-mail email@example.com).
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Salim I. KHAKOO, Collin R. BROOKS; MHC class I receptors on natural killer cells: on with the old and in with the new. Clin Sci (Lond) 1 August 2003; 105 (2): 127–140. doi: https://doi.org/10.1042/CS20030095
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