The aim of this cohort study was to determine whether periodontitis and gingivitis are associated with impaired salivary antioxidant status and increased oxidative injury. One hundred and twenty-nine patients attending a routine dental check-up were recruited for the study. Periodontal disease status was characterized using the Community Periodontal Index of Treatment Needs (CPITN) system. Total salivary antioxidant capacity and salivary ascorbate, urate and albumin were determined in a sample of whole unstimulated saliva. Protein carbonyl concentrations were determined as an index of oxidative injury. Patients in the lowest tertile of CPITN score exhibited decreased salivary delivery of antioxidants and specifically urate than patients in the upper tertile. Poor periodontal health was associated with increased concentrations of protein carbonyls in saliva. Women had significantly lower total antioxidant status than men, regardless of periodontal health. Periodontal disease is associated with reduced salivary antioxidant status and increased oxidative damage within the oral cavity.
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Research Article|
August 01 2003
Periodontal disease is associated with lower antioxidant capacity in whole saliva and evidence of increased protein oxidation
Dean V. SCULLEY;
Dean V. SCULLEY
1Division of Nutritional Biochemistry, School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, Leicestershire LE12 5RD, U.K.
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Simon C. LANGLEY-EVANS
1Division of Nutritional Biochemistry, School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, Leicestershire LE12 5RD, U.K.
Correspondence: Dr Simon Langley-Evans (e-mail [email protected]).
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Publisher: Portland Press Ltd
Received:
January 24 2003
Revision Received:
March 14 2003
Accepted:
March 21 2003
Accepted Manuscript online:
March 21 2003
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2003 The Biochemical Society
2003
Clin Sci (Lond) (2003) 105 (2): 167–172.
Article history
Received:
January 24 2003
Revision Received:
March 14 2003
Accepted:
March 21 2003
Accepted Manuscript online:
March 21 2003
Citation
Dean V. SCULLEY, Simon C. LANGLEY-EVANS; Periodontal disease is associated with lower antioxidant capacity in whole saliva and evidence of increased protein oxidation. Clin Sci (Lond) 1 August 2003; 105 (2): 167–172. doi: https://doi.org/10.1042/CS20030031
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