We have previously reported that modest dietary sodium restriction, as advocated in management guidelines for diabetes, may reduce insulin sensitivity. It has since been suggested that this effect may be mediated via cross-talk between insulin and angiotensin II (AII)-stimulated intracellular second messengers. In order to assess the effect of 5 days of modest sodium restriction (to <80 mmol/day target sodium intake) on insulin sensitivity, 15 healthy males underwent a double-blind, placebo-controlled, randomized, cross-over euglycaemic hyperinsulinaemic clamp study. One phase was supplemented with sodium tablets and the other with matched placebo. Insulin sensitivity (M) was reduced during dietary sodium restriction [median M value, 10.2 mg/kg per min (interquartile range 9.50–13.85) versus 12.8 mg/kg per min (interquartile range 9.60–14.30), P<0.05]. To elucidate potential mechanisms that may explain this observation, we investigated the effect of AII on insulin action in isolated adipocytes obtained from healthy females. No effect of AII on insulin-mediated glucose transport or suppression of lipolysis was observed. In conclusion, despite the observation that dietary sodium restriction was associated with a median 15% reduction in insulin sensitivity, we found no evidence of a direct effect of AII on insulin action in human adipocytes.
Skip Nav Destination
Article navigation
August 2003
-
Cover Image
Cover Image
- PDF Icon PDF LinkTable of Contents
Research Article|
August 01 2003
Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin II on insulin action
Colin G. PERRY;
*Division of Cardiovascular and Medical Sciences, University of Glasgow, Gardiner Institute, Western Infirmary, Glasgow G11 6NT, U.K.
Correspondence: Dr Colin Perry (e-mail [email protected]).
Search for other works by this author on:
Tim PALMER;
Tim PALMER
†Henry Wellcome Memorial Laboratory for Cell Biology, Institute of Biomedical and Life Sciences, Davidson Building, University of Glasgow, Glasgow G12 8QQ, U.K.
Search for other works by this author on:
Steven J. CLELAND;
Steven J. CLELAND
*Division of Cardiovascular and Medical Sciences, University of Glasgow, Gardiner Institute, Western Infirmary, Glasgow G11 6NT, U.K.
Search for other works by this author on:
Ian J. MORTON;
Ian J. MORTON
*Division of Cardiovascular and Medical Sciences, University of Glasgow, Gardiner Institute, Western Infirmary, Glasgow G11 6NT, U.K.
Search for other works by this author on:
Ian P. SALT;
Ian P. SALT
†Henry Wellcome Memorial Laboratory for Cell Biology, Institute of Biomedical and Life Sciences, Davidson Building, University of Glasgow, Glasgow G12 8QQ, U.K.
Search for other works by this author on:
John R. PETRIE;
John R. PETRIE
*Division of Cardiovascular and Medical Sciences, University of Glasgow, Gardiner Institute, Western Infirmary, Glasgow G11 6NT, U.K.
Search for other works by this author on:
Gwyn W. GOULD;
Gwyn W. GOULD
†Henry Wellcome Memorial Laboratory for Cell Biology, Institute of Biomedical and Life Sciences, Davidson Building, University of Glasgow, Glasgow G12 8QQ, U.K.
Search for other works by this author on:
John M. C. CONNELL
John M. C. CONNELL
*Division of Cardiovascular and Medical Sciences, University of Glasgow, Gardiner Institute, Western Infirmary, Glasgow G11 6NT, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
November 12 2002
Revision Received:
April 08 2003
Accepted:
April 29 2003
Accepted Manuscript online:
April 29 2003
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2003 The Biochemical Society
2003
Clin Sci (Lond) (2003) 105 (2): 187–194.
Article history
Received:
November 12 2002
Revision Received:
April 08 2003
Accepted:
April 29 2003
Accepted Manuscript online:
April 29 2003
Citation
Colin G. PERRY, Tim PALMER, Steven J. CLELAND, Ian J. MORTON, Ian P. SALT, John R. PETRIE, Gwyn W. GOULD, John M. C. CONNELL; Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin II on insulin action. Clin Sci (Lond) 1 August 2003; 105 (2): 187–194. doi: https://doi.org/10.1042/CS20020320
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |