The aim of the present study was to determine the effects of labour and mode of delivery on human placental and fetal membrane content of adrenomedullin (AdM). Placentas and fetal membranes were collected either at term or pre-term gestation from women either in labour or not in labour, and AdM was measured in tissue extracts by specific RIA. There were significant increases in AdM concentrations in amnion and choriodecidua for the in-labour group compared with the not-in-labour group for both pre-term and term gestations. There was no difference in AdM concentration in placental tissue between labour groups. This study provides evidence that fetal membrane AdM is increased in amniotic and choriodecidual tissues in response to labour, and suggests that it may play a role during human labour.
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October 2003
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Research Article|
October 01 2003
Labour-associated changes in adrenomedullin content in human placenta and fetal membranes
A. AL-GHAFRA;
*Department of Perinatal Medicine, Royal Women's Hospital, 132 Grattan Street, Carlton, VIC 3053, Australia
†Department of Obstetrics and Gynaecology, University of Melbourne, Grattan Street, Parkville, VIC 3052, Australia
Correspondence: Dr Alfia Al-Ghafra, Department of Perinatal Medicine, Royal Women's Hospital, 132 Grattan Street, Carlton, VIC 3053, Australia (e-mail [email protected]).
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N. M. GUDE;
N. M. GUDE
*Department of Perinatal Medicine, Royal Women's Hospital, 132 Grattan Street, Carlton, VIC 3053, Australia
†Department of Obstetrics and Gynaecology, University of Melbourne, Grattan Street, Parkville, VIC 3052, Australia
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S. P. BRENNECKE;
S. P. BRENNECKE
*Department of Perinatal Medicine, Royal Women's Hospital, 132 Grattan Street, Carlton, VIC 3053, Australia
†Department of Obstetrics and Gynaecology, University of Melbourne, Grattan Street, Parkville, VIC 3052, Australia
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R. G. KING
R. G. KING
‡Department of Pharmacology, Monash University, PO Box 13E, Wellington Road, VIC 3800, Australia
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Publisher: Portland Press Ltd
Received:
January 22 2003
Revision Received:
April 29 2003
Accepted:
May 27 2003
Accepted Manuscript online:
May 27 2003
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2003 The Biochemical Society
2003
Clin Sci (Lond) (2003) 105 (4): 419–423.
Article history
Received:
January 22 2003
Revision Received:
April 29 2003
Accepted:
May 27 2003
Accepted Manuscript online:
May 27 2003
Citation
A. AL-GHAFRA, N. M. GUDE, S. P. BRENNECKE, R. G. KING; Labour-associated changes in adrenomedullin content in human placenta and fetal membranes. Clin Sci (Lond) 1 October 2003; 105 (4): 419–423. doi: https://doi.org/10.1042/CS20030027
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