Uric acid (UA) possesses free-radical-scavenging properties, and systemic administration is known to increase serum antioxidant capacity. However, it is not known whether this protects against oxidative stress. The effects of raising UA concentration were studied during acute aerobic physical exercise in healthy subjects, as a model of oxidative stress characterized by increased circulating 8-iso-prostaglandin F2α (8-iso-PGF2α) concentrations. Twenty healthy subjects were recruited to a randomized double-blind placebo-controlled crossover study, and underwent systemic administration of 0.5 g of UA in 250 ml of 0.1% lithium carbonate/4% dextrose vehicle or vehicle alone as control. subjects performed high-intensity aerobic exercise for 20 min to induce oxidative stress. Plasma 8-iso-PGF2α concentrations were determined at baseline, after exercise and after recovery for 20 min. A single bout of high-intensity exercise caused a significant increase in plasma 8-iso-PGF2α concentrations from 35.0±4.7 pg/ml to 45.6±6.7 pg/ml (P<0.01). UA administration raised serum urate concentration from 293±16 to 487±16 μmol/l (P<0.001), accompanied by increased serum antioxidant capacity from 1786±39 to 1899±45 μmol/l (P<0.01). UA administration abolished the exercise-induced elevation of plasma 8-iso-PGF2α concentrations. High UA concentrations are associated with increased serum antioxidant capacity and reduced oxidative stress during acute physical exercise in healthy subjects. These findings indicate that the antioxidant properties of UA are of biological importance in vivo.
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October 2003
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Research Article|
October 01 2003
Uric acid reduces exercise-induced oxidative stress in healthy adults
W. S. WARING;
*Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, U.K.
Correspondence: Dr W. Stephen Waring ([email protected]).
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A. CONVERY;
A. CONVERY
*Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, U.K.
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V. MISHRA;
V. MISHRA
†Department of Clinical Chemistry, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, U.K.
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A. SHENKIN;
A. SHENKIN
†Department of Clinical Chemistry, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, U.K.
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D. J. WEBB;
D. J. WEBB
*Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, U.K.
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S. R. J. MAXWELL
S. R. J. MAXWELL
*Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, U.K.
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Publisher: Portland Press Ltd
Received:
April 23 2003
Revision Received:
May 27 2003
Accepted:
June 12 2003
Accepted Manuscript online:
June 12 2003
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2003 The Biochemical Society
2003
Clin Sci (Lond) (2003) 105 (4): 425–430.
Article history
Received:
April 23 2003
Revision Received:
May 27 2003
Accepted:
June 12 2003
Accepted Manuscript online:
June 12 2003
Citation
W. S. WARING, A. CONVERY, V. MISHRA, A. SHENKIN, D. J. WEBB, S. R. J. MAXWELL; Uric acid reduces exercise-induced oxidative stress in healthy adults. Clin Sci (Lond) 1 October 2003; 105 (4): 425–430. doi: https://doi.org/10.1042/CS20030149
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