During positive pressure mechanical ventilation, percentile systolic pressure variation (%SPV) or respiratory-related arterial pressure variability (RAPV) have both been used in assessment of graded haemorrhage. We aimed to investigate whether changes in %SPV and RAPV are correlated during graded haemorrhage (by 5, 10 or 20% of the estimated blood volume) in anaesthetized positive pressure ventilated rats and to investigate the involvement of autonomic regulation. Saline vehicle or atropine produced no discernible effect on baseline %SPV or RAPV but, thereafter, %SPV and RAPV increased progressively with graded haemorrhage. Propranolol significantly decreased baseline %SPV and RAPV and changes induced in %SPV and RAPV by graded haemorrhage. Phentolamine significantly enhanced baseline %SPV and RAPV, and further enhancement of %SPV and RAPV by graded haemorrhage did not occur until 20% of the estimated blood volume was removed. RAPV was significantly correlated with %SPV in all experimental groups. We conclude that RAPV is comparable with%SPV as an indicator of graded haemorrhage and that, in anaesthetized and positive pressure ventilated rats, both are dependent on autonomic function, especially β-adrenoceptors.
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October 2003
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Research Article|
October 01 2003
Respiratory-related arterial pressure variability as an indicator of graded blood loss: involvement of the autonomic nervous system
Hsien Yong LAI
;
Hsien Yong LAI
*Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan
†Department of Anesthesiology, Tzu Chi Buddhist General Hospital, Hualien 970, Taiwan
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Cheryl C. H. YANG
;
Cheryl C. H. YANG
‡Department of Physiology, Tzu Chi University, Hualien 970, Taiwan
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Fan-Yen HUANG
;
Fan-Yen HUANG
§Department of Anesthesiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan
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Yi LEE
;
Yi LEE
†Department of Anesthesiology, Tzu Chi Buddhist General Hospital, Hualien 970, Taiwan
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Yu Ling KUO
;
Yu Ling KUO
‡Department of Physiology, Tzu Chi University, Hualien 970, Taiwan
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Terry B. J. KUO
║Institute of Neuroscience, Tzu Chi University, Hualien 970, Taiwan
Correspondence: Professor Terry B. J. Kuo (e-mail tcskuo@ms33.hinet.net).
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Clin Sci (Lond) (2003) 105 (4): 491–497.
Article history
Received:
February 28 2003
Revision Received:
May 19 2003
Accepted:
June 20 2003
Accepted Manuscript online:
June 20 2003
Citation
Hsien Yong LAI, Cheryl C. H. YANG, Fan-Yen HUANG, Yi LEE, Yu Ling KUO, Terry B. J. KUO; Respiratory-related arterial pressure variability as an indicator of graded blood loss: involvement of the autonomic nervous system. Clin Sci (Lond) 1 October 2003; 105 (4): 491–497. doi: https://doi.org/10.1042/CS20030080
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