The angiotensinogen M235T polymorphism has been linked to hypertension and cardiovascular disease. Carotid intima-media thickness (IMT) is an early marker of atherosclerosis. The objectives of the present study were to determine in previously untreated essential hypertensive patients whether carotid IMT was associated with the M235T polymorphism, and to determine whether the M235T polymorphism could influence the reduction of carotid IMT by antihypertensive treatment. Common carotid artery IMT was determined with a high-definition echotracking system in 98 previously untreated hypertensive patients in a cross-sectional study. A subgroup of 56 patients was included in a randomized double-blind parallel group study comparing the effect of the angiotensin-converting-enzyme-inhibitor enalapril with that of the β-blocker celiprolol during a 5 month period. In the cross-sectional study, a multivariate analysis showed that the M235T genotype was a significant independent determinant of carotid IMT, explaining 7% of the variance. Carotid IMT was higher in patients homozygous for the T allele than in MM patients. In the longitudinal study, the reduction in carotid IMT after antihypertensive treatment was significantly (P<0.01) higher in patients carrying the TT genotype than in patients carrying the MM genotype, despite similar reductions in blood pressure and independently of drug type. In conclusion, these data suggest that the angiotensinogen TT genotype at position 235 is a genetic marker for early carotid atherosclerosis in a hypertensive population and its regression under antihypertensive treatment.
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November 2003
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Research Article|
November 01 2003
Angiotensinogen gene M235T polymorphism and reduction in wall thickness in response to antihypertensive treatment
Erwan BOZEC;
Erwan BOZEC
*Department of Pharmacology, INSERM EMI 0107, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
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Céline FASSOT;
Céline FASSOT
*Department of Pharmacology, INSERM EMI 0107, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
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Anne-Isabelle TROPEANO;
Anne-Isabelle TROPEANO
*Department of Pharmacology, INSERM EMI 0107, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
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Pierre BOUTOUYRIE;
Pierre BOUTOUYRIE
*Department of Pharmacology, INSERM EMI 0107, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
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Xavier JEUNEMAITRE;
Xavier JEUNEMAITRE
†Department of Molecular Biology, INSERM U36, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
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Patrick LACOLLEY;
Patrick LACOLLEY
*Department of Pharmacology, INSERM EMI 0107, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
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Hubert DABIRE;
Hubert DABIRE
*Department of Pharmacology, INSERM EMI 0107, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
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Stéphane LAURENT
*Department of Pharmacology, INSERM EMI 0107, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
Correspondence: Professor Stéphane Laurent (e-mail stephane.laurent@egp.ap-hop-paris.fr).
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Publisher: Portland Press Ltd
Received:
April 29 2003
Revision Received:
July 21 2003
Accepted:
August 12 2003
Accepted Manuscript online:
August 12 2003
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2003 The Biochemical Society
2003
Clin Sci (Lond) (2003) 105 (5): 637–644.
Article history
Received:
April 29 2003
Revision Received:
July 21 2003
Accepted:
August 12 2003
Accepted Manuscript online:
August 12 2003
Citation
Erwan BOZEC, Céline FASSOT, Anne-Isabelle TROPEANO, Pierre BOUTOUYRIE, Xavier JEUNEMAITRE, Patrick LACOLLEY, Hubert DABIRE, Stéphane LAURENT; Angiotensinogen gene M235T polymorphism and reduction in wall thickness in response to antihypertensive treatment. Clin Sci (Lond) 1 November 2003; 105 (5): 637–644. doi: https://doi.org/10.1042/CS20030156
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