Subclinical left ventricular (LV) dysfunction may be identified by reduced longitudinal contraction. We sought to define the effects of subclinical LV dysfunction on radial contractility in 53 patients with diabetes mellitus with no LV hypertrophy, normal ejection fraction and no ischaemia as assessed by dobutamine echocardiography, in comparison with age-matched controls. Radial peak myocardial systolic velocity (Sm) and early diastolic velocity (Em), strain and strain rate were measured in the mid-posterior and mid-anteroseptal walls in parasternal views and each variable was averaged for individual patients (radial contractility). These variables were also measured in the mid-posterior and mid-anteroseptal walls in the apical long-axis view and each variable was averaged for individual patients (longitudinal contractility). Mean radial Sm, strain and strain rate were significantly increased in diabetic patients (2.9±0.6 cm/s, 28±5% and 1.8±0.4 s-1 respectively) compared with controls (2.4±0.7 cm/s, 23±4% and 1.6±0.3 s-1 respectively; all P<0.001), but there was no difference in Em (3.3±1.2 compared with 3.1±1.1 cm/s, P=not significant). In contrast, longitudinal Sm, Em, strain and strain rate were significantly lower in diabetic patients (3.6±1.1 cm/s, 4.3±1.6 cm/s, 21±4% and 1.6±0.3 s-1 respectively) than in controls (4.3±1.0 cm/s, 5.7±2.3 cm/s, 26±4% and 1.9±0.3 s-1 respectively; all P ⩽ 0.001). Thus radial contractility appears to compensate for reduced longitudinal contractility in subclinical LV dysfunction occurring in the absence of ischaemia or LV hypertrophy.
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January 2004
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Research Article|
January 01 2004
Relationship between longitudinal and radial contractility in subclinical diabetic heart disease
Zhi You FANG;
Zhi You FANG
1Department of Medicine, University of Queensland, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland 4012, Australia
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Rodel LEANO;
Rodel LEANO
1Department of Medicine, University of Queensland, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland 4012, Australia
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Thomas H. MARWICK
1Department of Medicine, University of Queensland, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland 4012, Australia
Correspondence: Professor T. Marwick (e-mail [email protected]).
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Publisher: Portland Press Ltd
Received:
April 25 2003
Revision Received:
July 30 2003
Accepted:
August 19 2003
Accepted Manuscript online:
August 19 2003
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2004 The Biochemical Society
2004
Clin Sci (Lond) (2004) 106 (1): 53–60.
Article history
Received:
April 25 2003
Revision Received:
July 30 2003
Accepted:
August 19 2003
Accepted Manuscript online:
August 19 2003
Citation
Zhi You FANG, Rodel LEANO, Thomas H. MARWICK; Relationship between longitudinal and radial contractility in subclinical diabetic heart disease. Clin Sci (Lond) 1 January 2004; 106 (1): 53–60. doi: https://doi.org/10.1042/CS20030153
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