Disturbed vasomotor function in coronary arteries has clinical importance in early stages of coronary artery disease (CAD), as it may contribute to the potential risk for an ischaemic coronary event. In the present study, we have investigated the relationship between coronary vasomotor function and the extent of CAD. The response to acetylcholine and nitrate infusion was assessed by quantitative coronary angiography. The extent of CAD was categorized into two groups: minor CAD (normal coronary arteries and vessel wall irregularities) and significant CAD (one-, two- and three-vessel disease). A total of 277 patients with stable angina pectoris, referred for a first diagnostic coronary angiography, were eligible for analysis (mean age 57 years, 61% male). The response to nitrate was significantly impaired in patients with significant CAD (P<0.001). On the other hand, the response to acetylcholine was not different between the two groups (P=0.12); however, a trend between the response to acetylcholine and the extent of CAD was observed in patients without a previous infarction (P=0.07), which was a significant interaction variable. Furthermore, a significant relationship between coronary vasomotor response and the number of cardiovascular risk factors was observed (P<0.05). In conclusion, in a heterogeneous group of patients, coronary vasomotor function measured by nitrate infusion was more strongly associated with the extent of CAD and the number of risk factors than the response to acetylcholine. These data suggest that, in patients with advanced atherosclerosis or multiple risk factors, the vasomotor dysfunction is not solely restricted to the endothelium.
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February 2004
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Research Article|
February 01 2004
Coronary vasomotor response is related to the angiographic extent of coronary sclerosis in patients with stable angina pectoris
Folkert W. ASSELBERGS;
Folkert W. ASSELBERGS
1
*Department of Clinical Pharmacology, University of Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands
†Department of Cardiology, University Hospital Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands
Correspondence: Dr Folkert W. Asselbergs (e-mail [email protected]).
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Stefan H.J. MONNINK;
Stefan H.J. MONNINK
1
†Department of Cardiology, University Hospital Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands
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Nic J.G.M. VEEGER;
Nic J.G.M. VEEGER
‡Trial Coordination Center, University Hospital Groningen, Groningen 9713 GZ, The Netherlands
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Ad J. VAN BOVEN;
Ad J. VAN BOVEN
†Department of Cardiology, University Hospital Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands
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Paul L. VAN HAELST;
Paul L. VAN HAELST
†Department of Cardiology, University Hospital Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands
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Gillian A.J. JESSURUN;
Gillian A.J. JESSURUN
†Department of Cardiology, University Hospital Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands
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Wiek H. VAN GILST;
Wiek H. VAN GILST
*Department of Clinical Pharmacology, University of Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands
†Department of Cardiology, University Hospital Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands
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René A. TIO
René A. TIO
†Department of Cardiology, University Hospital Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands
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Publisher: Portland Press Ltd
Received:
June 24 2003
Revision Received:
August 22 2003
Accepted:
September 04 2003
Accepted Manuscript online:
September 04 2003
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2004 The Biochemical Society
2004
Clin Sci (Lond) (2004) 106 (2): 115–120.
Article history
Received:
June 24 2003
Revision Received:
August 22 2003
Accepted:
September 04 2003
Accepted Manuscript online:
September 04 2003
Citation
Folkert W. ASSELBERGS, Stefan H.J. MONNINK, Nic J.G.M. VEEGER, Ad J. VAN BOVEN, Paul L. VAN HAELST, Gillian A.J. JESSURUN, Wiek H. VAN GILST, René A. TIO; Coronary vasomotor response is related to the angiographic extent of coronary sclerosis in patients with stable angina pectoris. Clin Sci (Lond) 1 February 2004; 106 (2): 115–120. doi: https://doi.org/10.1042/CS20030215
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