Transfer function analysis has become one of the main techniques to study the dynamic relationship between cerebral blood flow and arterial blood pressure, but the influence of different respiratory rates on cerebral blood flow has not been fully investigated. In 14 healthy volunteers, middle cerebral artery blood flow velocity, recorded using transcranial Doppler ultrasound, non-invasive beat-to-beat Finapres blood pressure, ECG and end-tidal CO2 (PETCO2) levels were recorded with subjects resting supine and breathing spontaneously or at controlled rates of 6, 10 and 15 breaths/min. Transfer function analysis and impulse and step responses were computed at each respiratory rate. PETCO2 levels tended to fall slightly during paced respiration, especially at 15 breaths/min. Controlled breathing rates did not alter transfer function analysis in the frequency range below 0.08 Hz but, above this frequency, the coherence function contained significant peaks corresponding to the respiratory frequencies. The impulse response was similar at all breathing rates, but the step response was characteristic of more efficient autoregulation with reduced PETCO2 levels associated with increasing respiratory rate. The effects of breathing rate and rhythmicity and PETCO2 must be considered in studies of cerebral autoregulation.
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February 2004
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Research Article|
February 01 2004
Influence of controlled breathing patterns on cerebrovascular autoregulation and cardiac baroreceptor sensitivity
Penelope J. EAMES;
*University of Leicester Division of Medicine for the Elderly, The Glenfield Hospital, Leicester LE3 9QP, U.K.
Correspondence: Dr Penny Eames (e-mail [email protected]).
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John F. POTTER;
John F. POTTER
*University of Leicester Division of Medicine for the Elderly, The Glenfield Hospital, Leicester LE3 9QP, U.K.
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Ronney B. PANERAI
Ronney B. PANERAI
†Department of Medical Physics, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, U.K.
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Publisher: Portland Press Ltd
Received:
June 03 2003
Revision Received:
August 07 2003
Accepted:
October 01 2003
Accepted Manuscript online:
October 01 2003
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2004 The Biochemical Society
2004
Clin Sci (Lond) (2004) 106 (2): 155–162.
Article history
Received:
June 03 2003
Revision Received:
August 07 2003
Accepted:
October 01 2003
Accepted Manuscript online:
October 01 2003
Citation
Penelope J. EAMES, John F. POTTER, Ronney B. PANERAI; Influence of controlled breathing patterns on cerebrovascular autoregulation and cardiac baroreceptor sensitivity. Clin Sci (Lond) 1 February 2004; 106 (2): 155–162. doi: https://doi.org/10.1042/CS20030194
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