In the present study, myogenic properties of femoral arteries from control hindlimbs and those distal to external iliac artery partial ligation of spontaneously hypertensive rats (SHRs) and normotensive Wistar–Kyoto (WKY) rats were assessed. Arterial pressure was reduced distal to the ligature in both strains. Media thickness/lumen diameter (M/L) ratios of control (unligatured) SHRs were greater than in unligatured WKY rats and were reduced in arteries distal to the ligature (ligatured) within each strain. In none of the comparisons was a greater M/L ratio associated with greater maximal myogenic contractions, but increased M/L ratios were associated with a shift of myogenic activity to a higher pressure range in all comparisons. SHR ligatured arteries produced greater pressure-dependent contractile responses than WKY rat unligatured arteries, although arterial structures were not significantly different. Wall stress was similar in all arteries within the 60–120 mmHg pressure range with myogenic tone in spite of large differences in arterial structure. The utilization of arteries with experimentally altered structure provides further evidence that increased M/L ratios are not associated with greater peak pressure-dependent contractile responses and that arterial wall stress is maintained within a narrow range through an interaction between arterial wall geometry and smooth muscle contractile function.
Skip Nav Destination
Article navigation
February 2004
-
Cover Image
Cover Image
- PDF Icon PDF LinkTable of Contents
Research Article|
February 01 2004
Influence of experimental reduction of media/lumen ratio on arterial myogenic properties of spontaneously hypertensive and Wistar–Kyoto rats
Jennifer M. HUGHES;
Jennifer M. HUGHES
1Department of Human Anatomy and Physiology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 2, Ireland
Search for other works by this author on:
Stuart J. BUND
1Department of Human Anatomy and Physiology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 2, Ireland
Correspondence: Dr Stuart J. Bund (e-mail [email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
July 04 2003
Revision Received:
August 29 2003
Accepted:
September 17 2003
Accepted Manuscript online:
September 17 2003
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2004 The Biochemical Society
2004
Clin Sci (Lond) (2004) 106 (2): 163–171.
Article history
Received:
July 04 2003
Revision Received:
August 29 2003
Accepted:
September 17 2003
Accepted Manuscript online:
September 17 2003
Citation
Jennifer M. HUGHES, Stuart J. BUND; Influence of experimental reduction of media/lumen ratio on arterial myogenic properties of spontaneously hypertensive and Wistar–Kyoto rats. Clin Sci (Lond) 1 February 2004; 106 (2): 163–171. doi: https://doi.org/10.1042/CS20030225
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Cited By
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |