A multitude of studies in experimental animals, together with clinical data, provide evidence that increased production of ROS (reactive oxygen species) are involved in the development and progression of cardiovascular disease. As ROS appear to have a critical role in atherosclerosis, there has been considerable interest in identifying the enzyme systems involved and in developing strategies to reduce oxidative stress. Prospective clinical trials with vitamins and hormone replacement therapy have not fulfilled earlier promises, although there is still interest in other dietary supplements. Superoxide dismutase mimetics, thiols, xanthine oxidase and NAD(P)H oxidase inhibitors are currently receiving much interest, while animal studies using gene therapy show promise, but are still at an early stage. Of the drugs in common clinical use, there is evidence that ACE (angiotensin-converting enzyme) inhibitors and AT1(angiotensin II type 1) receptor blockers have beneficial effects on oxidative stress above their antihypertensive properties, whereas statins, in addition to improving lipid profiles, may also lower oxidative stress.
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March 01 2004
Strategies to reduce oxidative stress in cardiovascular disease
Carlene A. HAMILTON;
Carlene A. HAMILTON
1British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, 44 Church Street, Western Infirmary, Glasgow G11 6NT, Scotland, U.K.
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William H. MILLER;
William H. MILLER
1British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, 44 Church Street, Western Infirmary, Glasgow G11 6NT, Scotland, U.K.
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Sammy AL-BENNA;
Sammy AL-BENNA
1British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, 44 Church Street, Western Infirmary, Glasgow G11 6NT, Scotland, U.K.
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M. Julia BROSNAN;
M. Julia BROSNAN
1British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, 44 Church Street, Western Infirmary, Glasgow G11 6NT, Scotland, U.K.
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Russell D. DRUMMOND;
Russell D. DRUMMOND
1British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, 44 Church Street, Western Infirmary, Glasgow G11 6NT, Scotland, U.K.
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Martin W. McBRIDE;
Martin W. McBRIDE
1British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, 44 Church Street, Western Infirmary, Glasgow G11 6NT, Scotland, U.K.
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Anna F. DOMINICZAK
1British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, 44 Church Street, Western Infirmary, Glasgow G11 6NT, Scotland, U.K.
Correspondence: Professor Anna F. Dominiczak (e-mail [email protected]).
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Publisher: Portland Press Ltd
Received:
November 19 2003
Revision Received:
December 15 2003
Accepted:
December 16 2003
Accepted Manuscript online:
January 21 2004
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2004 The Biochemical Society
2004
Clin Sci (Lond) (2004) 106 (3): 219–234.
Article history
Received:
November 19 2003
Revision Received:
December 15 2003
Accepted:
December 16 2003
Accepted Manuscript online:
January 21 2004
Citation
Carlene A. HAMILTON, William H. MILLER, Sammy AL-BENNA, M. Julia BROSNAN, Russell D. DRUMMOND, Martin W. McBRIDE, Anna F. DOMINICZAK; Strategies to reduce oxidative stress in cardiovascular disease. Clin Sci (Lond) 1 March 2004; 106 (3): 219–234. doi: https://doi.org/10.1042/CS20030379
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