The majority of clinical studies demonstrate that patients with hyperhomocysteinaemia have an increased risk of atherothrombotic events. However, there is a striking and poorly understood heterogeneity in the severity of clinical features in individuals with hyperhomocysteinaemia. This observation suggests that other factors must exist that modulate the relationship between hyperhomocysteinaemia and clinical disease. Therefore identifying factors that inhibit or enhance the vasculotoxic effects of homocysteine is important, as is elucidation of how homocysteine damages blood vessels. This comment discusses the study of Woodman and colleagues in this issue of Clinical Science in which they investigate the effects of hyperhomocysteinaemia on endothelial function.
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April 2004
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Commentary|
April 01 2004
Can mild-to-moderate hyperhomocysteinaemia impair endothelial function in the absence of other risk factors for cardiovascular disease?
Marina L. H. HONING;
Marina L. H. HONING
1Department of Internal Medicine, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
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Coen D. A. STEHOUWER
1Department of Internal Medicine, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Correspondence: Professor Coen Stehouwer (e-mail [email protected]).
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Publisher: Portland Press Ltd
Received:
November 27 2003
Accepted:
December 04 2003
Accepted Manuscript online:
December 04 2003
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2004 The Biochemical Society
2004
Clin Sci (Lond) (2004) 106 (4): 345–346.
Article history
Received:
November 27 2003
Accepted:
December 04 2003
Accepted Manuscript online:
December 04 2003
Citation
Marina L. H. HONING, Coen D. A. STEHOUWER; Can mild-to-moderate hyperhomocysteinaemia impair endothelial function in the absence of other risk factors for cardiovascular disease?. Clin Sci (Lond) 1 April 2004; 106 (4): 345–346. doi: https://doi.org/10.1042/CS20030391
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