In the present study, we observed the haemodynamic changes, using echocardiography and Doppler, in ten healthy volunteers during 6 h of compression in a hyperbaric chamber with a protocol designed to reproduce the conditions as near as possible to a real dive. Ambient pressure varied from 1.6 to 3 atm (1 atm=101.325 kPa) and partial pressure of inspired O2 from 1.2 to 2.8 atm. Subjects performed periods of exercise with breathing through a closed-circuit self-contained underwater breathing apparatus (SCUBA). Subjects did not eat or drink during the study. Examinations were performed after 15 min and 5 h. After 15 min, stroke volume (SV), left atrial (LA) diameter and left ventricular (LV) end-diastolic diameter (LVEDD) decreased. Heart rate (HR) and cardiac output (CO) did not vary, but indices of the LV systolic performance decreased by 10% and the LV meridional wall stress increased by 17%. After 5 h, although weight decreased, the serum protein concentration increased. Compared with values obtained after 15 min, SV and CO decreased, but LV systolic performance, LA diameter, LVEDD and LV meridional wall stress remained unchanged. Compared with the reference values obtained at sea level, total arterial compliance decreased, HR remained unchanged and CO decreased. In conclusion, hyperbaric hyperoxia results in significant haemodynamic changes. Initially, hyperoxia and the SCUBA system are responsible for reducing LV preload, increasing LV afterload and decreasing LV systolic performance, although CO did not change. Prolonged exposure resulted in a further decrease in LV preload, because of dehydration, and in a further increase in LV afterload, due to systemic vasoconstriction, with the consequence of decreasing CO.
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April 2004
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Research Article|
April 01 2004
Haemodynamic effects of hyperbaric hyperoxia in healthy volunteers: an echocardiographic and Doppler study
Florence MOLÉNAT;
*Service de Réanimation Médico-Chirurgicale et de Surveillance Continue, Centre Hospitalier du pays d'Aix, Aix en Provence, France
Correspondence: Dr Florence Molenat (e-mail [email protected]).
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Alain BOUSSUGES;
Alain BOUSSUGES
†Laboratoire de Recherche EA 3280, “Physiopathologie et action thérapeutique des gaz sous pression”, Faculté de Médecine Nord, Marseille, France
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Aliocha GRANDFOND;
Aliocha GRANDFOND
†Laboratoire de Recherche EA 3280, “Physiopathologie et action thérapeutique des gaz sous pression”, Faculté de Médecine Nord, Marseille, France
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Jean-Claude ROSTAIN;
Jean-Claude ROSTAIN
†Laboratoire de Recherche EA 3280, “Physiopathologie et action thérapeutique des gaz sous pression”, Faculté de Médecine Nord, Marseille, France
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Jean-Marie SAINTY;
Jean-Marie SAINTY
†Laboratoire de Recherche EA 3280, “Physiopathologie et action thérapeutique des gaz sous pression”, Faculté de Médecine Nord, Marseille, France
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Claude ROBINET;
Claude ROBINET
‡Institut de Médecine Navale et de Santé des Armées, Hôpital Militaire Saint-Anne, Toulon, France
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François GALLAND;
François GALLAND
‡Institut de Médecine Navale et de Santé des Armées, Hôpital Militaire Saint-Anne, Toulon, France
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Jean Louis MELIET
Jean Louis MELIET
‡Institut de Médecine Navale et de Santé des Armées, Hôpital Militaire Saint-Anne, Toulon, France
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Publisher: Portland Press Ltd
Received:
September 03 2003
Revision Received:
November 07 2003
Accepted:
November 28 2003
Accepted Manuscript online:
November 28 2003
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2004 The Biochemical Society
2004
Clin Sci (Lond) (2004) 106 (4): 389–395.
Article history
Received:
September 03 2003
Revision Received:
November 07 2003
Accepted:
November 28 2003
Accepted Manuscript online:
November 28 2003
Citation
Florence MOLÉNAT, Alain BOUSSUGES, Aliocha GRANDFOND, Jean-Claude ROSTAIN, Jean-Marie SAINTY, Claude ROBINET, François GALLAND, Jean Louis MELIET; Haemodynamic effects of hyperbaric hyperoxia in healthy volunteers: an echocardiographic and Doppler study. Clin Sci (Lond) 1 April 2004; 106 (4): 389–395. doi: https://doi.org/10.1042/CS20030293
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