There is increasing evidence to implicate inflammation as an important precursor of endothelial dysfunction. This mechanistic link is apparent across the entire spectrum of inflammatory status, i.e. endothelial function is apparent following acute infection, and in subjects with chronic high-grade inflammation and, perhaps most importantly, persistent low-grade inflammation. The recognition of this relationship has present therapeutic ramifications, but also requires that future longitudinal studies determining the predictive ability of endothelial function measures for vascular events should incorporate markers of inflammation as potential confounders. In this issue of Clinical Science, Fichtlscherer and co-workers describe a link between endothelial function and sPLA2 (secretory non-pancreatic type II phospholipase A2) serum activity.
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May 2004
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Commentary|
May 01 2004
Inflammation and endothelial dysfunction: intimate companions in the pathogenesis of vascular disease?
Naveed SATTAR
1Department of Vascular Biochemistry, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, U.K.
Correspondence: Dr Naveed Sattar (e-mail nsattar@clinmed.gla.ac.uk).
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Clin Sci (Lond) (2004) 106 (5): 443–445.
Article history
Received:
January 19 2004
Accepted:
January 26 2004
Accepted Manuscript online:
January 26 2004
Citation
Naveed SATTAR; Inflammation and endothelial dysfunction: intimate companions in the pathogenesis of vascular disease?. Clin Sci (Lond) 1 May 2004; 106 (5): 443–445. doi: https://doi.org/10.1042/CS20040019
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