To determine the effect of training on insulin sensitivity (IS) and how this relates to peak VO2 (peak oxygen uptake) in CHF (chronic heart failure), 77 CHF patients (New York Heart Association class, II/III; men/women, 59/18; age, 60±9 years; body mass index, 26.7±3.9 kg/m2; left ventricular ejection fraction, 26.9±8.1%; expressed as means±S.D.) participated in the study. Patients were randomly assigned to a training or control group (TrG or CG respectively). Sixty-one patients completed the study. Patients participated in training (combined strength and endurance exercises) four times per week, two times supervised and two times at home. Before and after intervention, anthropometry, IS (euglycaemic hyperinsulinaemic clamp) and peak VO2 (incremental cycle ergometry) were assessed. Intervention did not affect IS significantly, even though IS increased by 20% in TrG and 11% in CG (not significant). Peak VO2 increased as a result of training (6% increase in TrG; 2% decrease in CG; P<0.05). In both groups (TrG and CG), the change in IS correlated positively with the change in peak VO2 (r=0.30, P<0.05). Training resulted in an increase in peak VO2, but not in IS. Whether physical training actually increases IS in CHF patients remains unclear.
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May 2004
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Research Article|
May 01 2004
Does physical training increase insulin sensitivity in chronic heart failure patients?
L. W. E. SABELIS;
*Department of Sports Medicine, University Medical Centre, Utrecht, The Netherlands
Correspondence: Dr Louise W. E. Sabelis ([email protected]).
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P. J. SENDEN;
P. J. SENDEN
†Department of Cardiology, Meander Medical Centre, Amersfoort, The Netherlands
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B. C. M. TE BOEKHORST;
B. C. M. TE BOEKHORST
*Department of Sports Medicine, University Medical Centre, Utrecht, The Netherlands
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H. J. HULZEBOS;
H. J. HULZEBOS
‡Department of Rehabilitation, University Medical Centre, Utrecht, The Netherlands
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A. VAN DE WIEL;
A. VAN DE WIEL
§Internal Medicine, Meander Medical Centre, Amersfoort, The Netherlands
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T. W. VAN HAEFTEN;
T. W. VAN HAEFTEN
║Department of Internal Medicine, University Medical Centre, Utrecht, The Netherlands
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M. L. ZONDERLAND;
M. L. ZONDERLAND
*Department of Sports Medicine, University Medical Centre, Utrecht, The Netherlands
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W. L. MOSTERD
W. L. MOSTERD
*Department of Sports Medicine, University Medical Centre, Utrecht, The Netherlands
†Department of Cardiology, Meander Medical Centre, Amersfoort, The Netherlands
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Publisher: Portland Press Ltd
Received:
July 29 2003
Revision Received:
December 02 2003
Accepted:
December 05 2003
Accepted Manuscript online:
December 05 2003
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2004 The Biochemical Society
2004
Clin Sci (Lond) (2004) 106 (5): 459–466.
Article history
Received:
July 29 2003
Revision Received:
December 02 2003
Accepted:
December 05 2003
Accepted Manuscript online:
December 05 2003
Citation
L. W. E. SABELIS, P. J. SENDEN, B. C. M. TE BOEKHORST, H. J. HULZEBOS, A. VAN DE WIEL, T. W. VAN HAEFTEN, M. L. ZONDERLAND, W. L. MOSTERD; Does physical training increase insulin sensitivity in chronic heart failure patients?. Clin Sci (Lond) 1 May 2004; 106 (5): 459–466. doi: https://doi.org/10.1042/CS20030254
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