Recently, conflicting data have been reported regarding the possible contribution of the TSP-4 (thrombospondin-4) A387P polymorphism to CAD (coronary artery disease) or MI (myocardial infarction). To investigate a possible association between the A387P polymorphism and CAD or MI in the Chinese Han population, we conducted a case-controlled study including 817 patients with angiographically verified CAD or those who survived an acute MI and 847 control subjects. The TSP-4 A387P polymorphism was determined by PCR and PCR-RFLP (restriction-fragment-length polymorphism) analysis. The prevalence of the 387P allele was 3.8% in the healthy controls, which was less frequent than those in Western populations (19.6–23.2%). No association of the A387P polymorphism with an altered risk of CAD, MI or premature MI was found in our present study (CG+CC compared with GG, PCAD=0.51, PMI=0.13, PPremature MI=0.17 respectively). We concluded that a relationship between the TSP-4 A387P polymorphism and CAD or MI was unlikely in our population. Additional investigations should be performed in populations at different risk of coronary events in order to elucidate further the possible contribution of this polymorphism to cardiovascular disease.
Skip Nav Destination
Article navigation
May 2004
-
Cover Image
Cover Image
- PDF Icon PDF LinkTable of Contents
Research Article|
May 01 2004
Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han population
Xiaoyang ZHOU;
Xiaoyang ZHOU
*Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Rd, Beijing 100037, People's Republic of China
†National Human Genome Center at Beijing, North Yongchang Rd 3-707, Beijing 100176, People's Republic of China
Search for other works by this author on:
Jianfeng HUANG;
Jianfeng HUANG
*Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Rd, Beijing 100037, People's Republic of China
Search for other works by this author on:
Jianhong CHEN;
Jianhong CHEN
*Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Rd, Beijing 100037, People's Republic of China
Search for other works by this author on:
Jiangong ZHAO;
Jiangong ZHAO
*Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Rd, Beijing 100037, People's Republic of China
Search for other works by this author on:
Wenjie YANG;
Wenjie YANG
*Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Rd, Beijing 100037, People's Republic of China
Search for other works by this author on:
Xiaoling WANG;
Xiaoling WANG
*Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Rd, Beijing 100037, People's Republic of China
Search for other works by this author on:
Dongfeng GU
*Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Rd, Beijing 100037, People's Republic of China
†National Human Genome Center at Beijing, North Yongchang Rd 3-707, Beijing 100176, People's Republic of China
Correspondence: Dr Dongfeng Gu (e-mail [email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
September 30 2003
Revision Received:
November 28 2003
Accepted:
December 16 2003
Accepted Manuscript online:
December 16 2003
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2004 The Biochemical Society
2004
Clin Sci (Lond) (2004) 106 (5): 495–500.
Article history
Received:
September 30 2003
Revision Received:
November 28 2003
Accepted:
December 16 2003
Accepted Manuscript online:
December 16 2003
Citation
Xiaoyang ZHOU, Jianfeng HUANG, Jianhong CHEN, Jiangong ZHAO, Wenjie YANG, Xiaoling WANG, Dongfeng GU; Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han population. Clin Sci (Lond) 1 May 2004; 106 (5): 495–500. doi: https://doi.org/10.1042/CS20030322
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |