17β-Oestradiol (E2; oestrogen) is known to increase endothelium-dependent vasodilatation and NO (nitric oxide) production. It is also known to decrease the response of VSMCs (vascular smooth muscle cells) to vasoconstrictors in vitro. E2 induces a decrease in age-related BP (blood pressure) development in MSHR (male spontaneously hypertensive rats). Whether this decrease is due to an effect on the endothelium or smooth muscle is unknown. To determine this effect, we examined the role of E2 on vascular endothelium and smooth muscle separately. We treated MSHR with E2 (2 mg·kg-1 of body weight·week-1) for 5–7 weeks and then examined the vasoconstrictor response in the intact and denuded rings (with or without endothelium respectively). SBP (systolic BP) was measured weekly. Aortic cGMP and cAMP contents, aortic vasoconstrictor response, endothelium suppression of the vasoconstrictor response and basal NO release from aortic rings were all measured at the end of the study. We found that the age-related development of SBP in MSHR was decreased in E2-treated rats. The vascular response of denuded rings to a vasoconstrictor (phenylephrine and KCl) was increased in E2-treated rats; however, this phenomenon was masked in intact rings. The enhanced endothelial function appears to override the E2-increased smooth muscle vasoconstrictor response. Endothelium suppression, NO release and aortic cGMP content were all significantly higher in E2-treated rats than in controls. Thus our results suggest that E2 improves endothelium function; furthermore, the accompanied NO/cGMP increase and the endothelium suppression may be associated with an E2-induced BP-lowering effect in MSHR.
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May 2004
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Research Article|
May 01 2004
17β-Oestradiol enhances aortic endothelium function and smooth muscle contraction in male spontaneously hypertensive rats
Chia-Hung YEN;
Chia-Hung YEN
*Department of Physiology and Pharmacology, Chang Gung University College of Medicine, 259 Wen Hwa 1 Rd., Kwei-Shan, Taoyuan, Taiwan, Republic of China
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Ying-Tung LAU
*Department of Physiology and Pharmacology, Chang Gung University College of Medicine, 259 Wen Hwa 1 Rd., Kwei-Shan, Taoyuan, Taiwan, Republic of China
†Department of Life Science, Chang Gung University College of Medicine, 259 Wen Hwa 1 Rd., Kwei-Shan, Taoyuan, Taiwan, Republic of China
Correspondence: Dr Ying-Tung Lau, Department of Physiology and Pharmacology, Department of Life Science, Chang Gung University College of Medicine, 259 Wen Hwa 1 Rd, Kwei-Shan, Taoyuan, Taiwan, Republic of China (e-mail [email protected]).
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Publisher: Portland Press Ltd
Received:
October 13 2003
Revision Received:
December 23 2003
Accepted:
January 08 2004
Accepted Manuscript online:
January 08 2004
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2004 The Biochemical Society
2004
Clin Sci (Lond) (2004) 106 (5): 541–546.
Article history
Received:
October 13 2003
Revision Received:
December 23 2003
Accepted:
January 08 2004
Accepted Manuscript online:
January 08 2004
Citation
Chia-Hung YEN, Ying-Tung LAU; 17β-Oestradiol enhances aortic endothelium function and smooth muscle contraction in male spontaneously hypertensive rats. Clin Sci (Lond) 1 May 2004; 106 (5): 541–546. doi: https://doi.org/10.1042/CS20030334
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