Atherosclerosis has two key components, thickening and stiffening of arterial wall. These parameters are quantified ultrasonographically by IMT (intima-media thickness) and PWV (pulse wave velocity). In the present study, we determined the FA IMT (IMT of the bilateral femoral artery) and PWV of femoral–ankle (PWV fa) and brachial–ankle (PWV ba) segments in order to examine whether the degree of atherosclerosis is different between paretic and non-paretic lower limbs in 24 patients with hemiparesis. The values of PWV fa, PWV ba and FA IMT were all significantly greater on the paretic than the non-paretic side. Furthermore, significant decreases in masses of muscle, bone and fat, determined by dual-energy X-ray absorptiometry, were observed in paretic lower limbs compared with the non-paretic side. PWV fa correlated significantly and negatively with muscle mass (r=-0.488, P=0.0004) and tended to correlate negatively with BMC (bone mineral content; r=-0.264, P=0.069) when statistical analyses were performed with the paretic and non-paretic sides together. Multiple regression analysis elucidated that the muscle mass was associated significantly with PWV fa and PWV ba, independent of age, duration after cerebrovascular accident, gender, bone and fat mass and FA IMT. The muscle mass was still associated with increased PWV fa and PWV ba when multivariate analysis was conducted independently in the paretic and non-paretic sides. In summary, our results indicated that arterial thickening and stiffening were greater on the paretic than the non-paretic side and suggested that a decrease of muscle mass might be associated with increased arterial stiffening in the paretic lower limb.
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June 01 2004
Increased arterial stiffening and thickening in the paretic lower limb in patients with hemiparesis
Reiko OKABE;
Reiko OKABE
*Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
†Department of Internal Medicine, Hanwa Second Senboku Hospital, 3176, Fukai Kitamachi, Sakai City, Osaka 599-8271, Japan
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Masaaki INABA;
*Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
Correspondence: Dr Masaaki Inaba ([email protected]).
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Shinrei SAKAI;
Shinrei SAKAI
*Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
†Department of Internal Medicine, Hanwa Second Senboku Hospital, 3176, Fukai Kitamachi, Sakai City, Osaka 599-8271, Japan
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Eiji ISHIMURA;
Eiji ISHIMURA
*Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
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Atsushi MORIGUCHI;
Atsushi MORIGUCHI
†Department of Internal Medicine, Hanwa Second Senboku Hospital, 3176, Fukai Kitamachi, Sakai City, Osaka 599-8271, Japan
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Tetsuo SHOJI;
Tetsuo SHOJI
*Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
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Yoshiki NISHIZAWA
Yoshiki NISHIZAWA
*Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
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Publisher: Portland Press Ltd
Received:
November 24 2003
Revision Received:
January 26 2004
Accepted:
February 05 2004
Accepted Manuscript online:
February 05 2004
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2004 The Biochemical Society
2004
Clin Sci (Lond) (2004) 106 (6): 613–618.
Article history
Received:
November 24 2003
Revision Received:
January 26 2004
Accepted:
February 05 2004
Accepted Manuscript online:
February 05 2004
Citation
Reiko OKABE, Masaaki INABA, Shinrei SAKAI, Eiji ISHIMURA, Atsushi MORIGUCHI, Tetsuo SHOJI, Yoshiki NISHIZAWA; Increased arterial stiffening and thickening in the paretic lower limb in patients with hemiparesis. Clin Sci (Lond) 1 June 2004; 106 (6): 613–618. doi: https://doi.org/10.1042/CS20030387
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