In the present issue of Clinical Science, Brown and co-workers report preliminary results of Ang I (angiotensin I) immunization in humans. They demonstrate the presence of antibodies in human plasma and report that the procedure is well tolerated, but the blood pressure does not fall. The first attempts to actively immunize against components of the renin–angiotensin system were performed by Goldblatt in the 1950s. In our experience, active immunization against renin was associated with a complete inhibition of endogeneous plasma renin activity and a decrease in blood pressure, followed by the progressive development of a juxtaglomerular autoimmune nephritis. In contrast neither blood pressure nor aldosterone secretion were significantly modified by Ang I immunization. Moreover, Ang I-immunized animals continued to respond to the pharmacological inhibition of renin–angiotensin system. These data provide evidence of the inability of antibodies to target Ang I within tissues.
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August 2004
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Commentary|
July 27 2004
Renin–angiotensin vaccine: old story, new project ‘efficacy versus safety’
Jean-Baptiste MICHEL
1Inserm Unit 460, CHU Xavier Bichat, 46 rue Henri Huchard, 75877 Paris cedex 18, France
Correspondence: Professor Jean-Baptiste Michel (email [email protected]).
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Publisher: Portland Press Ltd
Received:
April 19 2004
Accepted:
April 23 2004
Accepted Manuscript online:
April 23 2004
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2004
Clin Sci (Lond) (2004) 107 (2): 145–147.
Article history
Received:
April 19 2004
Accepted:
April 23 2004
Accepted Manuscript online:
April 23 2004
Connected Content
A commentary has been published:
Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjects
Citation
Jean-Baptiste MICHEL; Renin–angiotensin vaccine: old story, new project ‘efficacy versus safety’. Clin Sci (Lond) 1 August 2004; 107 (2): 145–147. doi: https://doi.org/10.1042/CS20040116
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