A decreased LFP (low-frequency power) spectral component of HRV [HR (heart rate) variability] is a risk factor for sudden death in patients with CHF (chronic heart failure). In the present study, we evaluated factors (age, arterial pressures and HR) influencing LFP and HFP (high-frequency power) components in short-term recordings during controlled breathing in patients with CHF or hypertension, and healthy normotensive subjects. In patients with CHF, we also compared LFP values with known markers of sudden death [NYHA (New York Heart Association) class, HR and ejection fraction]. All HRV measures were significantly lower in patients with CHF than in hypertensive and normotensive subjects (P<0.001), and in hypertensive than in normotensive subjects (P<0.05). Stepwise multiple regression analysis showed that, in patients with CHF, LFP was inversely associated with NYHA class (β=−0.5, P<0.0001) and HR (β=−0.2, P=0.001) and was positively associated with ejection fraction (β=0.28, P<0.0001). In patients with CHF, LFP remained unchanged with age. In normotensive and hypertensive subjects, HFP decreased with age, but in patients with CHF it did not. In the ≥60<70 and ≥70 years of age subgroups, we found no difference between HFP in the three groups studied. Hence, in normotensives and hypertensives, LFP tended to diminish with age (β=−0.4, P<0.0001 in normotensives; β=−0.4, P<0.001 in hypertensives) and was inversely associated with HR (β=−0.2, P=0.002 in normotensives; β=−0.3, P=0.002 in hypertensives). Conversely, in patients with CHF, LFP is predominantly influenced by NYHA class, HR and ejection fraction, but not by age. LFP might therefore increase the sensitivity of factors already used in stratifying the risk of sudden death in patients with CHF.
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August 2004
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Research Article|
July 27 2004
Factors influencing heart rate variability power spectral analysis during controlled breathing in patients with chronic heart failure or hypertension and in healthy normotensive subjects
Gianfranco PICCIRILLO;
1Dipartimento di Scienze dell'Invecchiamento, Policlinico Umberto I, Università “La Sapienza”, Rome, Italy
Correspondence: Dr Gianfranco Piccirillo (email [email protected]).
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Damiano MAGRÌ;
Damiano MAGRÌ
1Dipartimento di Scienze dell'Invecchiamento, Policlinico Umberto I, Università “La Sapienza”, Rome, Italy
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Camilla NASO;
Camilla NASO
1Dipartimento di Scienze dell'Invecchiamento, Policlinico Umberto I, Università “La Sapienza”, Rome, Italy
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Silvia di CARLO;
Silvia di CARLO
1Dipartimento di Scienze dell'Invecchiamento, Policlinico Umberto I, Università “La Sapienza”, Rome, Italy
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Antonio MOISÈ;
Antonio MOISÈ
1Dipartimento di Scienze dell'Invecchiamento, Policlinico Umberto I, Università “La Sapienza”, Rome, Italy
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Tiziana DE LAURENTIS;
Tiziana DE LAURENTIS
1Dipartimento di Scienze dell'Invecchiamento, Policlinico Umberto I, Università “La Sapienza”, Rome, Italy
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Alessia TORRINI;
Alessia TORRINI
1Dipartimento di Scienze dell'Invecchiamento, Policlinico Umberto I, Università “La Sapienza”, Rome, Italy
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Sabrina MATERA;
Sabrina MATERA
1Dipartimento di Scienze dell'Invecchiamento, Policlinico Umberto I, Università “La Sapienza”, Rome, Italy
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Marialuce NOCCO
Marialuce NOCCO
1Dipartimento di Scienze dell'Invecchiamento, Policlinico Umberto I, Università “La Sapienza”, Rome, Italy
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Publisher: Portland Press Ltd
Received:
December 04 2003
Revision Received:
March 12 2004
Accepted:
March 26 2004
Accepted Manuscript online:
March 26 2004
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2004
Clin Sci (Lond) (2004) 107 (2): 183–190.
Article history
Received:
December 04 2003
Revision Received:
March 12 2004
Accepted:
March 26 2004
Accepted Manuscript online:
March 26 2004
Citation
Gianfranco PICCIRILLO, Damiano MAGRÌ, Camilla NASO, Silvia di CARLO, Antonio MOISÈ, Tiziana DE LAURENTIS, Alessia TORRINI, Sabrina MATERA, Marialuce NOCCO; Factors influencing heart rate variability power spectral analysis during controlled breathing in patients with chronic heart failure or hypertension and in healthy normotensive subjects. Clin Sci (Lond) 1 August 2004; 107 (2): 183–190. doi: https://doi.org/10.1042/CS20030401
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