We read with interest the article by Seko and colleagues [1], who document that serum levels of endostatin and VEGF (vascular endothelial growth factor) are increased markedly in patients with acute myocardial infarction, but subsequently decrease significantly by early reperfusion. We would like to point out important limitations in their findings not addressed in the study. This relates entirely to the administration of intravenous heparin during the reperfusion process. Firstly, we disagree that the significant decrease seen in serum VEGF levels 3–6 h after reperfusion relates to a down-regulation of VEGF production, but, in fact, is entirely due to intravenous heparin administration, which is known to modulate the interaction of VEGF with its receptor [2]. Kawamoto et al. [3] found that the serum concentration of VEGF in patients with acute myocardial infarction was reduced by up to 93% 1 h...

You do not currently have access to this content.