Patients with CRF (chronic renal failure) are at increased risk of cardiovascular diseases, and 60% of cardiovascular mortality in CRF is attributed to sudden death. Various abnormalities in myocardial repolarization are associated with the risk of ventricular arrhythmia. The aim of this study was to evaluate an index of temporal myocardial repolarization lability, the temporal QTVI (QT variability index), in patients with CRF. ECGs were recorded in 153 patients with CRF on haemodialysis (n=67), continuous ambulatory peritoneal dialysis (n=43) or conservative treatment (n=43) during 30 min of rest. QTVI was calculated as the logarithm of the ratio between the variances of the normalized QT and RR intervals. Age-matched healthy subjects (n=39) were examined for comparison. QTVI was increased by 47% in CRF patients compared with healthy subjects (−0.82±0.56 compared with −1.54±0.27 respectively; P<0.01). QTVI did not differ among patients on dialysis or conservative treatment, whereas QTVI was elevated further in patients with diabetes compared with non-diabetic CRF patients (−0.56±0.54 compared with −0.94±0.52 respectively; P<0.01). In a multiple linear regression analysis, diabetes and a history of coronary artery disease were the only independent predictors of QTVI in the CRF population. The present study demonstrates that elevated QTVI in patients with CRF is associated with diabetes and coronary disease. The present findings are important given that repolarization instability may predispose to ventricular arrhythmia and sudden death, events that occur frequently in CRF patients.
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December 2004
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Research Article|
November 24 2004
Elevated temporal QT variability index in patients with chronic renal failure
Mats JOHANSSON;
*Department of Clinical Physiology, Sahlgrenska University Hospital, Göteborg, Sweden
†Department of Internal Medicine, Varberg Hospital, Varberg, Sweden
Correspondence: Dr Mats Johansson, Department of Clinical Physiology, Sahlgrenska University Hospital, Göteborg, Sweden (email [email protected]).
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Sinsia A. GAO;
Sinsia A. GAO
*Department of Clinical Physiology, Sahlgrenska University Hospital, Göteborg, Sweden
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Peter FRIBERG;
Peter FRIBERG
*Department of Clinical Physiology, Sahlgrenska University Hospital, Göteborg, Sweden
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Marita ANNERSTEDT;
Marita ANNERSTEDT
‡Department of Nephrology, Sahlgrenska University Hospital, Göteborg, Sweden
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Göran BERGSTRÖM;
Göran BERGSTRÖM
*Department of Clinical Physiology, Sahlgrenska University Hospital, Göteborg, Sweden
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Jan CARLSTRÖM;
Jan CARLSTRÖM
§Department of Nephrology, Norra Älvsborg Hospital, Vänersborg, Sweden
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Ted IVARSSON;
Ted IVARSSON
∥Department of Nephrology, Skövde Hospital, Skövde, Sweden
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Gert JENSEN;
Gert JENSEN
‡Department of Nephrology, Sahlgrenska University Hospital, Göteborg, Sweden
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Susanne LJUNGMAN;
Susanne LJUNGMAN
‡Department of Nephrology, Sahlgrenska University Hospital, Göteborg, Sweden
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Öivind MATHILLAS;
Öivind MATHILLAS
¶Department of Nephrology, Lundby Hospital, Göteborg, Sweden
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Finn-David NIELSEN;
Finn-David NIELSEN
**Department of Nephrology, Borås Hospital, Borås, Sweden
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Ulf STRÖMBOM
Ulf STRÖMBOM
††Department of Nephrology, Varberg Hospital, Varberg, Sweden
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Publisher: Portland Press Ltd
Received:
April 23 2004
Revision Received:
August 11 2004
Accepted:
August 18 2004
Accepted Manuscript online:
August 18 2004
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2004
Clin Sci (Lond) (2004) 107 (6): 583–588.
Article history
Received:
April 23 2004
Revision Received:
August 11 2004
Accepted:
August 18 2004
Accepted Manuscript online:
August 18 2004
Citation
Mats JOHANSSON, Sinsia A. GAO, Peter FRIBERG, Marita ANNERSTEDT, Göran BERGSTRÖM, Jan CARLSTRÖM, Ted IVARSSON, Gert JENSEN, Susanne LJUNGMAN, Öivind MATHILLAS, Finn-David NIELSEN, Ulf STRÖMBOM; Elevated temporal QT variability index in patients with chronic renal failure. Clin Sci (Lond) 1 December 2004; 107 (6): 583–588. doi: https://doi.org/10.1042/CS20040122
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