The morphology of gastrocnemius muscles was examined in RFPs (renal failure patients) being treated using HD (haemodialysis) and CAPD (continuous ambulatory peritoneal dialysis). RFPs (n=24) volunteered to participate in the present study. Twelve RFPs (five women and seven men; mean age, 55 years) were undergoing CAPD treatment and 12 RFPs (two women and ten men; mean age, 62 years) were undergoing HD treatment. Muscle biopsies from gastrocnemius muscles were found not to differ (P>0.05) in fibre type distribution, MyHC (myosin heavy chain) expression or fibre CSA (cross-sectional area) between the two groups. There were, however, significant differences (P<0.05) in CC/F (capillary contact/fibre), C/F (capillary to fibre ratio) and cytochrome c oxidase activity. The HD group had 33% more CC/F, with a 19% higher C/F and 33% greater cytochrome c activity in glycolytic fibres (II) than the CAPD group. There were no apparent differences in age, gender, co-morbidity, self-reported physical activity or physical functioning between the two groups, which could account for the difference in muscle capillarity between the groups. The HD patients were, however, administered heparin as a routine part of the dialysis therapy. The possibility is discussed that heparin in combination with mild anaemia and acidosis may have augmented angiogenesis in the HD patients.
Skip Nav Destination
Article navigation
December 2004
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Research Article|
November 24 2004
Skeletal muscle morphology and capillarization of renal failure patients receiving different dialysis therapies
Giorgos K. SAKKAS;
*Centre for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, Alsager ST7 2HL, U.K.
Correspondence: Dr Giorgos K. Sakkas, present address, Department of Medicine University of California, San Francisco, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, U.S.A. (email [email protected]).
Search for other works by this author on:
Derek BALL;
Derek BALL
*Centre for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, Alsager ST7 2HL, U.K.
Search for other works by this author on:
Anthony J. SARGEANT;
Anthony J. SARGEANT
*Centre for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, Alsager ST7 2HL, U.K.
†Institute for Fundamental and Clinical Human Movement Sciences, Vrije University, Amsterdam, The Netherlands
Search for other works by this author on:
Thomas H. MERCER;
Thomas H. MERCER
*Centre for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, Alsager ST7 2HL, U.K.
Search for other works by this author on:
Pelagia KOUFAKI;
Pelagia KOUFAKI
*Centre for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, Alsager ST7 2HL, U.K.
Search for other works by this author on:
Patrick F. NAISH
Patrick F. NAISH
‡Directorate of Renal Medicine, North Staffordshire Hospital Trust, Staffordshire ST4 7LN, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
August 26 2003
Revision Received:
May 28 2004
Accepted:
July 14 2004
Accepted Manuscript online:
July 14 2004
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2004
Clin Sci (Lond) (2004) 107 (6): 617–623.
Article history
Received:
August 26 2003
Revision Received:
May 28 2004
Accepted:
July 14 2004
Accepted Manuscript online:
July 14 2004
Citation
Giorgos K. SAKKAS, Derek BALL, Anthony J. SARGEANT, Thomas H. MERCER, Pelagia KOUFAKI, Patrick F. NAISH; Skeletal muscle morphology and capillarization of renal failure patients receiving different dialysis therapies. Clin Sci (Lond) 1 December 2004; 107 (6): 617–623. doi: https://doi.org/10.1042/CS20030282
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |