The present study examined the relationship between LV (left ventricular) function, markers of cardiac-specific damage and markers of oxidative stress in recreational runners following a marathon. Runners (n=52; 43 male and nine female; age, 35±10 years; height, 1.74±0.08 m; body mass, 75.9±8.9 kg) were assessed pre- and immediately post-marathon. LV function was assessed using standard M-mode two-dimensional Doppler echocardiography and TDI (tissue-Doppler imaging) echocardiography. Serum was analysed for cTnT (cardiac troponin-T), TEAC (Trolox equivalent antioxidant capacity; a measure of total antioxidant capacity), MDA (malondealdehyde) and 4-HNE (4-hydroxynonenal). A strong relationship was observed between standard and TDI echocardiography for all functional measures. Diastolic function was altered post-marathon characterized by a reduction in E (peak early diastolic filling: 0.79±0.11 compared with 0.64±0.16 cm/s; P<0.001), an increase in A (peak late diastolic filling: 0.48±0.11 compared with 0.60±0.12 cm/s; P<0.001) and a resultant decrease in E/A (ratio of E to A; 1.71±0.48 compared with 1.10±0.31; P<0.001). Ejection fraction remained unchanged post-marathon. Thirty-two runners presented with cTnT values above the lower limit of detection for the assay (0.01 μg/l), and 20 runners presented post-marathon with cTnT values above the acute myocardial infarction cut-off value (0.05 μg/l). No significant correlations were observed between cTnT and any functional measurements. MDA (2.90±1.58 compared with 3.59±1.47 μmol/l) and TEAC (1.80±0.12 compared with 1.89±0.21 mmol/l) were significantly increased post-marathon, but were unrelated to changes in function or cTnT. In conclusion, the present study demonstrated a reduction in diastolic function and widespread evidence of minimal cardiac damage following a marathon in recreational runners. The mechanism(s) underpinning the altered function and appearance of cTnT appear unrelated to reactive oxygen species.
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Research Article|
December 15 2004
Impact of marathon running on cardiac structure and function in recreational runners
Gregory WHYTE;
*Olympic Medical Institute, Northwick Park Hospital, Watford Road, Harrow HA1 3UJ, U.K.
Correspondence: Dr Greg Whyte (email greg.whyte@eis2win.co.uk).
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Keith GEORGE;
Keith GEORGE
†Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool L3 2ET, U.K.
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Robert SHAVE;
Robert SHAVE
‡Department of Sport Sciences, Brunel University, Uxbridge UB8 3PH, U.K.
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Ellen DAWSON;
Ellen DAWSON
§Department of Anaesthesia, Rigshospitalet, Copenhagen, Denmark
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Claire STEPHENSON;
Claire STEPHENSON
†Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool L3 2ET, U.K.
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Ben EDWARDS;
Ben EDWARDS
†Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool L3 2ET, U.K.
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David GAZE;
David GAZE
∥Department of Chemical Pathology, St. George's Hospital Medical School, Tooting, London SW17 0RE, U.K.
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David OXBOROUGH;
David OXBOROUGH
¶Department of Echocardiography, Nuffield Hospital, Leeds LS1 3EB, U.K.
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Jan FORSTER;
Jan FORSTER
**Siemens Ltd, Bracknell, RG12 8FZ, U.K.
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Rickie SIMSPON
Rickie SIMSPON
††Department of Sports Science, Napier University, Edinburgh EH10 5DT, U.K.
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Publisher: Portland Press Ltd
Received:
June 29 2004
Revision Received:
August 18 2004
Accepted:
September 20 2004
Accepted Manuscript online:
September 20 2004
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2005
Clin Sci (Lond) (2005) 108 (1): 73–80.
Article history
Received:
June 29 2004
Revision Received:
August 18 2004
Accepted:
September 20 2004
Accepted Manuscript online:
September 20 2004
Citation
Gregory WHYTE, Keith GEORGE, Robert SHAVE, Ellen DAWSON, Claire STEPHENSON, Ben EDWARDS, David GAZE, David OXBOROUGH, Jan FORSTER, Rickie SIMSPON; Impact of marathon running on cardiac structure and function in recreational runners. Clin Sci (Lond) 1 January 2005; 108 (1): 73–80. doi: https://doi.org/10.1042/CS20040186
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