In this issue of Clinical Science, Trang and co-workers report the results of short-term blood pressure and heart rate variability measurements in patients with congenital central hypoventilation syndrome (CCHS). The results reveal that these young patients disclose signs of vagal withdrawal and baroreflex failure. Baroreflex sensitivity was reduced by one third compared with the matched control subjects; however, patients have a relative preservation of the cardiac and vascular sympathetic function. These findings are clearly new and improve our understanding of CCHS physiopathology. Nevertheless, more research is needed to better delineate the respective contribution of cardiac vagal and sympathetic dysregulation, and the extent to which these abnormalities relate to genetic mutations as well as to clinical status.
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March 2005
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Commentary|
February 18 2005
New evidence of baroreflex dysfunction in congenital central hypoventilation syndrome
Philippe van de BORNE
1Department of Cardiology, Erasme Hospital, 808 Lennik Road, Brussels 1070, Belgium
Correspondence: Professor Philippe van de Borne (email pvandebo@ulb.ac.be).
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Clin Sci (Lond) (2005) 108 (3): 215–216.
Article history
Received:
December 15 2004
Accepted:
January 06 2005
Accepted Manuscript online:
January 06 2005
Connected Content
A commentary has been published:
Short-term blood pressure and heart rate variability in congenital central hypoventilation syndrome (Ondine's curse)
Citation
Philippe van de BORNE; New evidence of baroreflex dysfunction in congenital central hypoventilation syndrome. Clin Sci (Lond) 1 March 2005; 108 (3): 215–216. doi: https://doi.org/10.1042/CS20040360
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