In order to characterize BAL (bronchoalveolar lavage) in CEP (chronic eosinophilic pneumonia) and to investigate the possible role of mast cells and tryptase in the pathogenesis of this interstitial disease, cells and tryptase levels were determined in BAL of patients with CEP and in a group of healthy controls. The results show that a statistically significant increase in tryptase concentration was found in patients with CEP compared with the healthy controls. This is the first report that shows an increase in tryptase levels in CEP and could reflect higher mast cell activation as well as larger mast cell populations in the lungs of these patients. These results strongly support the involvement of mast cells and eosinophils in the immunopathogenesis of CEP.
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March 2005
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Research Article|
February 18 2005
Tryptase concentrations in bronchoalveolar lavage from patients with chronic eosinophilic pneumonia
Elena BARGAGLI;
1Respiratory Diseases Section, Department of Clinical Medicine and Immunological Sciences, Siena University, Le Scotte Hospital, 53100 Siena, Italy
Correspondence: Dr Elena Bargagli (email [email protected]).
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Caterina BIGLIAZZI;
Caterina BIGLIAZZI
1Respiratory Diseases Section, Department of Clinical Medicine and Immunological Sciences, Siena University, Le Scotte Hospital, 53100 Siena, Italy
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Alessandra LEONINI;
Alessandra LEONINI
1Respiratory Diseases Section, Department of Clinical Medicine and Immunological Sciences, Siena University, Le Scotte Hospital, 53100 Siena, Italy
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Nikolaos NIKIFORAKIS;
Nikolaos NIKIFORAKIS
1Respiratory Diseases Section, Department of Clinical Medicine and Immunological Sciences, Siena University, Le Scotte Hospital, 53100 Siena, Italy
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Maria G. PERARI;
Maria G. PERARI
1Respiratory Diseases Section, Department of Clinical Medicine and Immunological Sciences, Siena University, Le Scotte Hospital, 53100 Siena, Italy
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Paola ROTTOLI
Paola ROTTOLI
1Respiratory Diseases Section, Department of Clinical Medicine and Immunological Sciences, Siena University, Le Scotte Hospital, 53100 Siena, Italy
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Publisher: Portland Press Ltd
Received:
June 21 2004
Revision Received:
October 22 2004
Accepted:
November 11 2004
Accepted Manuscript online:
November 11 2004
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2005
Clin Sci (Lond) (2005) 108 (3): 273–276.
Article history
Received:
June 21 2004
Revision Received:
October 22 2004
Accepted:
November 11 2004
Accepted Manuscript online:
November 11 2004
Citation
Elena BARGAGLI, Caterina BIGLIAZZI, Alessandra LEONINI, Nikolaos NIKIFORAKIS, Maria G. PERARI, Paola ROTTOLI; Tryptase concentrations in bronchoalveolar lavage from patients with chronic eosinophilic pneumonia. Clin Sci (Lond) 1 March 2005; 108 (3): 273–276. doi: https://doi.org/10.1042/CS20040178
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