Although it is often recommended to standardize the time of day when performing non-invasive measurements of vascular function, the exact influence of the time of day on the outcome of IMT (intima-media thickness), PWV (pulse wave velocity), AIX (augmentation index) and FMD (flow-mediated dilatation) measurements has not been reported before. Nineteen healthy volunteers visited our department on two different occasions: the first visit was at 09:00 hours after an overnight fast, and the second visit was at 14:00 hours after a standardized breakfast. Non-invasive measurements of atherosclerosis were performed twice at 09:00 hours and once on the second visit at 14:00 hours. Measurement of IMT, PWV, AIX and FMD was reproducible according to the method of Bland and Altman. The absolute difference between repeated measurements at 09:00 hours showed no significant difference compared with the absolute difference between 09:00 and 14:00 hours for IMT (0.029±0.014 compared with 0.021±0.014 mm; P=0.27), PWV (0.63±0.50 compared with 0.75±0.74 m/s; P=0.52), AIX (4.0±4.0 compared with 5.5±5.2%; P=0.35) and FMD (3.8±3.7 compared with 4.2±2.9%; P=0.70). In conclusion, our results show that, in healthy volunteers during the daytime, IMT, PWV, AIX and FMD outcomes are not confounded by variation in the exact time of the examination as long as other (exogenous) conditions, including food intake, smoking and intake of alcohol, are carefully controlled for.
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May 2005
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Research Article|
April 22 2005
Variation in non-invasive measurements of vascular function in healthy volunteers during daytime
Ewoud ter AVEST
;
*Department of Medicine, Division of General Internal Medicine, University Medical Center, Nijmegen, The Netherlands
Correspondence: Dr Ewoud ter Avest (email E.teravest@aig.umcn.nl).
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Suzanne HOLEWIJN
;
Suzanne HOLEWIJN
†Vascular Laboratory, University Medical Center, Nijmegen, The Netherlands
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Anton F. H. STALENHOEF
;
Anton F. H. STALENHOEF
*Department of Medicine, Division of General Internal Medicine, University Medical Center, Nijmegen, The Netherlands
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Jacqueline de GRAAF
Jacqueline de GRAAF
*Department of Medicine, Division of General Internal Medicine, University Medical Center, Nijmegen, The Netherlands
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Clin Sci (Lond) (2005) 108 (5): 425–431.
Article history
Received:
October 15 2004
Revision Received:
December 07 2004
Accepted:
January 06 2005
Accepted Manuscript online:
January 06 2005
Citation
Ewoud ter AVEST, Suzanne HOLEWIJN, Anton F. H. STALENHOEF, Jacqueline de GRAAF; Variation in non-invasive measurements of vascular function in healthy volunteers during daytime. Clin Sci (Lond) 1 May 2005; 108 (5): 425–431. doi: https://doi.org/10.1042/CS20040300
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