In order to facilitate characterization of the circulating factor(s) in pre-eclampsia, the present study aimed to determine whether plasma from women with pre-eclampsia, which induces attenuated endothelial-dependent relaxation in human myometrial arteries, is also capable of inducing altered endothelial function in mouse vessels. Human vessels were isolated from myometrial biopsies taken from women with uncomplicated pregnancies (n=6). Mesenteric and uterine arteries were isolated from male, female, non-pregnant and pregnant C57B mice (n=24). Vessels were studied using a wire myograph and incubated with plasma (2%) from women with pre-eclampsia (n=12) or controls (n=12). Incubation of myometrial vessels from normal pregnant women with plasma from women with pre-eclampsia reduced endothelial-dependent relaxation. This effect was not reproduced in male or female mouse mesenteric or uterine vessels incubated with plasma from women with pre-eclampsia. In conclusion, there are species-specific differences in the actions of the circulating factor(s) on endothelial-dependent relaxation of human and mouse small arteries.
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May 2005
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Research Article|
April 22 2005
Altered endothelial function in isolated human myometrial vessels induced by plasma from women with pre-eclampsia is not reproducible in isolated mouse vessels
Jenny MYERS;
*Maternal and Fetal Health Research Centre, University of Manchester, Hathersage Road, Manchester M13 0JH, U.K.
Correspondence: Dr Jenny Myers (email [email protected]).
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Rachel IRVINE;
Rachel IRVINE
*Maternal and Fetal Health Research Centre, University of Manchester, Hathersage Road, Manchester M13 0JH, U.K.
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Joanna GILLHAM;
Joanna GILLHAM
*Maternal and Fetal Health Research Centre, University of Manchester, Hathersage Road, Manchester M13 0JH, U.K.
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Maureen MACLEOD;
Maureen MACLEOD
†Maternal and Child Health Sciences, Ninewells Hospital and Medical School, Dundee DD1 9SY, U.K.
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Gary MIRES;
Gary MIRES
†Maternal and Child Health Sciences, Ninewells Hospital and Medical School, Dundee DD1 9SY, U.K.
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Michael TAGGART;
Michael TAGGART
*Maternal and Fetal Health Research Centre, University of Manchester, Hathersage Road, Manchester M13 0JH, U.K.
‡Smooth Muscle Physiology Group, Cardiovascular Research, University of Manchester, Oxford Road, Manchester M13 9WL, U.K.
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Philip BAKER
Philip BAKER
*Maternal and Fetal Health Research Centre, University of Manchester, Hathersage Road, Manchester M13 0JH, U.K.
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Publisher: Portland Press Ltd
Received:
December 01 2004
Revision Received:
January 12 2005
Accepted:
January 26 2005
Accepted Manuscript online:
January 26 2005
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2005
Clin Sci (Lond) (2005) 108 (5): 457–462.
Article history
Received:
December 01 2004
Revision Received:
January 12 2005
Accepted:
January 26 2005
Accepted Manuscript online:
January 26 2005
Citation
Jenny MYERS, Rachel IRVINE, Joanna GILLHAM, Maureen MACLEOD, Gary MIRES, Michael TAGGART, Philip BAKER; Altered endothelial function in isolated human myometrial vessels induced by plasma from women with pre-eclampsia is not reproducible in isolated mouse vessels. Clin Sci (Lond) 1 May 2005; 108 (5): 457–462. doi: https://doi.org/10.1042/CS20040343
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