CRP (C-reactive protein) has not only emerged as a useful biomarker for cardiovascular disease, but also as a mediator of atherosclerosis. CRP directly activates vascular endothelial cells, amplifying the inflammatory response underlying atherogenesis. The expression of IL (interleukin)-8 appears to serve as one of the downstream effects of CRP. Kibayashi and co-workers in this issue of Clinical Science confirm that CRP induces IL-8 production in human aortic endothelial cells in vitro, via the activation of MAPKs (mitogen-activated protein kinases), an effect that can be inhibited by pitavastatin.
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Commentary| May 24 2005
C-reactive protein and statins: IL-8 as a molecular link?
Paul E. SZMITKO;
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Paul E. SZMITKO, Subodh VERMA; C-reactive protein and statins: IL-8 as a molecular link?. Clin Sci (Lond) 1 June 2005; 108 (6): 493–495. doi: https://doi.org/10.1042/CS20050093
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