The present study was designed to investigate the effects of low-dose ketanserin on BPV (blood pressure variability), BRS (baroreflex sensitivity) and organ damage in SHR (spontaneously hypertensive rats). Ketanserin was mixed in rat chow at an estimated dose of 0.1 mg·kg−1 of body weight·day−1. SHR were treated for 4 months. BP (blood pressure) was then recorded continuously for 24 h in a conscious state. After determination of BRS, rats were killed for organ damage evaluation. It was found that long-term treatment with low-dose ketanserin did not lower BP levels, but significantly decreased BPV, enhanced BRS and reduced organ damage in SHR. Multiple regression analysis showed that the decrease in left ventricular hypertrophy was most closely correlated (or associated) with the increase in BRS, whereas the decrease in aortic hypertrophy was most closely associated with the decrease in diastolic BPV and the amelioration in renal lesion, with the increase in BRS and the decrease in diastolic BPV. In conclusion, low-dose ketanserin produces organ protection independently of its BP-lowering action in SHR, and this organ protection was importantly attributable to the enhancement of BRS and decrease in BPV.
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Research Article|
May 24 2005
Effects of low-dose ketanserin on blood pressure variability, baroreflex sensitivity and end-organ damage in spontaneously hypertensive rats
He-Hui XIE;
He-Hui XIE
1Department of Pharmacology, Second Military Medical University, 325 Guo He Road, Shanghai 200433, People's Republic of China
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Fu-Ming SHEN;
Fu-Ming SHEN
1Department of Pharmacology, Second Military Medical University, 325 Guo He Road, Shanghai 200433, People's Republic of China
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Yong-Bing CAO;
Yong-Bing CAO
1Department of Pharmacology, Second Military Medical University, 325 Guo He Road, Shanghai 200433, People's Republic of China
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Hui-Lin LI;
Hui-Lin LI
1Department of Pharmacology, Second Military Medical University, 325 Guo He Road, Shanghai 200433, People's Republic of China
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Ding-Feng SU
1Department of Pharmacology, Second Military Medical University, 325 Guo He Road, Shanghai 200433, People's Republic of China
Correspondence: Professor Ding-Feng Su (email [email protected]).
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Publisher: Portland Press Ltd
Received:
October 25 2004
Revision Received:
January 04 2005
Accepted:
February 11 2005
Accepted Manuscript online:
February 11 2005
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2005
Clin Sci (Lond) (2005) 108 (6): 547–552.
Article history
Received:
October 25 2004
Revision Received:
January 04 2005
Accepted:
February 11 2005
Accepted Manuscript online:
February 11 2005
Citation
He-Hui XIE, Fu-Ming SHEN, Yong-Bing CAO, Hui-Lin LI, Ding-Feng SU; Effects of low-dose ketanserin on blood pressure variability, baroreflex sensitivity and end-organ damage in spontaneously hypertensive rats. Clin Sci (Lond) 1 June 2005; 108 (6): 547–552. doi: https://doi.org/10.1042/CS20040310
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