A new simple criterion for diagnosing metabolic syndrome was proposed in the third report of the NCEP (National Cholesterol Education Program). In the present study, we analysed the association between metabolic syndrome and insulin resistance to investigate the effects of the latter on the prevalence of metabolic syndrome based on the new criteria recommended in the ATP (Adult Treatment Panel) III report. A total of 7057 participants (4472 men and 2585 women), who underwent medical screening at the Sungkyunkwan University Kangbuk Samsung Hospital, were investigated. Fasting insulin levels were measured and components of the metabolic syndrome as defined by the ATP III report were determined. We also applied the criteria for abdominal obesity as defined by APC-WC (Asia–Pacific criteria for waist circumference). The prevalence of metabolic syndrome as defined by ATP III was 5.3% (5.0% in men and 5.8% in women) and 8.9% (8.1% in men and 10.3% in women) by APC-WC. The odds ratio for the metabolic syndrome was significantly higher in subjects with higher insulin resistance than in those with lower insulin resistance. The mean levels of HOMA (homoeostatic model assessment) and fasting insulin were significantly higher in those with more of the components of the metabolic syndrome. A high HOMA (≥2.56) and fasting insulin concentration (≥9.98 μIU/ml; where IU is international unit) were found to be independent risk factors of the metabolic syndrome by multiple regression analysis after adjusting for age, sex and body mass index (P<0.001). These results show that the metabolic syndrome is significantly correlated with the insulin resistance index, and that appropriate values of HOMA and fasting insulin concentration may serve as a helpful guide for the management of metabolic syndrome.
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June 2005
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Research Article|
May 24 2005
Relative risks of the metabolic syndrome according to the degree of insulin resistance in apparently healthy Korean adults
Seung-Ha PARK;
Seung-Ha PARK
1
*Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108 Pyung-Dong, Jongro-Ku, Seoul, South Korea
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Won-Young LEE;
Won-Young LEE
1
*Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108 Pyung-Dong, Jongro-Ku, Seoul, South Korea
Correspondence: Dr Won-Young Lee (email [email protected]).
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Eun-Jung RHEE;
Eun-Jung RHEE
*Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108 Pyung-Dong, Jongro-Ku, Seoul, South Korea
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Woo-Kyu JEON;
Woo-Kyu JEON
*Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108 Pyung-Dong, Jongro-Ku, Seoul, South Korea
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Byung-Ik KIM;
Byung-Ik KIM
*Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108 Pyung-Dong, Jongro-Ku, Seoul, South Korea
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Seung-Ho RYU;
Seung-Ho RYU
†Department of Occupational Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108 Pyung-Dong, Jongro-Ku, Seoul, South Korea
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Sun-Woo KIM
Sun-Woo KIM
*Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108 Pyung-Dong, Jongro-Ku, Seoul, South Korea
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Publisher: Portland Press Ltd
Received:
November 17 2004
Revision Received:
January 13 2005
Accepted:
January 26 2005
Accepted Manuscript online:
January 26 2005
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2005
Clin Sci (Lond) (2005) 108 (6): 553–559.
Article history
Received:
November 17 2004
Revision Received:
January 13 2005
Accepted:
January 26 2005
Accepted Manuscript online:
January 26 2005
Citation
Seung-Ha PARK, Won-Young LEE, Eun-Jung RHEE, Woo-Kyu JEON, Byung-Ik KIM, Seung-Ho RYU, Sun-Woo KIM; Relative risks of the metabolic syndrome according to the degree of insulin resistance in apparently healthy Korean adults. Clin Sci (Lond) 1 June 2005; 108 (6): 553–559. doi: https://doi.org/10.1042/CS20040331
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