Resistin is a member of a class of cysteine-rich proteins collectively termed resistin-like molecules. Resistin has been implicated in the pathogenesis of obesity-mediated insulin resistance and T2DM (Type II diabetes mellitus), at least in rodent models. In addition, resistin also appears to be a pro-inflammatory cytokine. Taken together, resistin, like many other adipocytokines, may possess a dual role in contributing to disease risk. However, to date there has been considerable controversy surrounding this 12.5 kDa polypeptide in understanding its physiological relevance in both human and rodent systems. Furthermore, this has led some to question whether resistin represents an important pathogenic factor in the aetiology of T2DM and cardiovascular disease. Although researchers still remain divided as to the role of resistin, this review will place available data on resistin in the context of our current knowledge of the pathogenesis of obesity-mediated diabetes, and discuss key controversies and developments.
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September 2005
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Review Article|
August 24 2005
Role of resistin in obesity, insulin resistance and Type II diabetes
Christine M. Kusminski;
Christine M. Kusminski
1Diabetes and Metabolism Research Laboratory, Clinical Sciences Research Institute, UHCW Trust, Clifford Bridge Road, Walsgrave, Coventry CV2 2DX, U.K.
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Philip G. Mcternan;
Philip G. Mcternan
1Diabetes and Metabolism Research Laboratory, Clinical Sciences Research Institute, UHCW Trust, Clifford Bridge Road, Walsgrave, Coventry CV2 2DX, U.K.
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Sudhesh Kumar
1Diabetes and Metabolism Research Laboratory, Clinical Sciences Research Institute, UHCW Trust, Clifford Bridge Road, Walsgrave, Coventry CV2 2DX, U.K.
Correspondence: Professor Sudhesh Kumar (email [email protected]).
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Publisher: Portland Press Ltd
Received:
February 25 2005
Revision Received:
April 01 2005
Accepted:
April 06 2005
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2005
Clin Sci (Lond) (2005) 109 (3): 243–256.
Article history
Received:
February 25 2005
Revision Received:
April 01 2005
Accepted:
April 06 2005
Citation
Christine M. Kusminski, Philip G. Mcternan, Sudhesh Kumar; Role of resistin in obesity, insulin resistance and Type II diabetes. Clin Sci (Lond) 1 September 2005; 109 (3): 243–256. doi: https://doi.org/10.1042/CS20050078
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