Systemic markers of inflammation may be increased in patients after percutaneous coronary intervention. In the present study, we evaluated whether IP (ischaemic preconditioning) attenuated inflammation by activating KATP (ATP-sensitive potassium) channels in patients undergoing coronary angioplasty. Patients (n=36) undergoing angioplasty of a major left coronary artery were allocated randomly to one of four groups: a control group, a group receiving nicorandil (an agonist of KATP channels), an IP group or an IP group pretreated with glibenclamide (an antagonist of KATP channels). To measure the release of sCD40L, P-selectin and myeloperoxidase from the ischaemic region, blood samples were drawn simultaneously from the ascending aorta and the great cardiac vein before and 15 min after coronary angioplasty. At 15 min after angioplasty, a significant increase in sCD40L and P-selectin levels in the great cardiac vein in the control group was observed. IP- and nicorandil-treated patients did not show a significant change in sCD40L and P-selectin levels in response to angioplasty. However, the IP-induced attenuation of sCD40L and P-selectin release was abolished by administering glibenclamide. The change in myeloperoxidase levels mirrored those of sCD40L and P-selectin. The levels of inflammatory markers in the aorta remained stable throughout the study. Patients undergoing angioplasty had increased sCD40L and P-selectin levels in the ischaemic region. In conclusion, IP abolished angioplasty-induced myeloperoxidase release by preventing activated platelet-induced P-selectin release via a KATP-channel-initiated pathway. Therefore, in addition to its primary effect on cardioprotection, IP may also provide beneficial anti-inflammatory effects on the interaction between platelets and neutrophils.
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September 2005
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Research Article|
August 24 2005
Effect of ischaemic preconditioning on regional release of inflammatory markers
Tsung-Ming Lee;
Tsung-Ming Lee
*Cardiology Section, Department of Medicine, Chi-Mei Medical Centre, Taipei Medical University, Tainan, Taiwan
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Mei-Shu Lin;
Mei-Shu Lin
†Department of Pharmacy, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
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Chang-Her Tsai;
Chang-Her Tsai
‡Cardiology Section, Department of Surgery, Chi-Mei Medical Centre, Taipei Medical University, Tainan, Taiwan
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Nen-Chung Chang
§Cardiology Section, Department of Medicine, Taipei Medical University and Hospital, Taipei, Taiwan
Correspondence: Professor Nen-Chung Chang (email [email protected]).
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Publisher: Portland Press Ltd
Received:
January 31 2005
Revision Received:
April 08 2005
Accepted:
May 18 2005
Accepted Manuscript online:
May 18 2005
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2005
Clin Sci (Lond) (2005) 109 (3): 267–276.
Article history
Received:
January 31 2005
Revision Received:
April 08 2005
Accepted:
May 18 2005
Accepted Manuscript online:
May 18 2005
Citation
Tsung-Ming Lee, Mei-Shu Lin, Chang-Her Tsai, Nen-Chung Chang; Effect of ischaemic preconditioning on regional release of inflammatory markers. Clin Sci (Lond) 1 September 2005; 109 (3): 267–276. doi: https://doi.org/10.1042/CS20050046
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