DLB (dementia with Lewy bodies) is a syndrome associated with underlying LBD (Lewy body disease), with manifestations in the cognitive, neuropsychiatric, motor, sleep and autonomic domains. The variable symptomatology and complex array of neuronal involvement and neurotransmitter deficiencies make the diagnosis and management of patients with DLB challenging. The genetic underpinnings of DLB have only recently begun to unfold. In this review, the clinical features, diagnostic criteria, genetics and treatment issues relating to DLB will be discussed, in which a comprehensive approach to the diagnosis and management is emphasized.
Review Article| September 23 2005
Clinical, diagnostic, genetic and management issues in dementia with Lewy bodies
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Bradley F. Boeve; Clinical, diagnostic, genetic and management issues in dementia with Lewy bodies. Clin Sci (Lond) 1 October 2005; 109 (4): 343–354. doi: https://doi.org/10.1042/CS20050098
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