Major progress has been made in the last decade in understanding the genetic basis of PD (Parkinson's disease) with five genes unequivocally associated with disease. As a result, multiple pathways have been implicated in the pathogenesis of PD, including proteasome impairment and mitochondrial dysfunction. Although Mendelian genetics has been successful in establishing a genetic predisposition for familial PD, this has not been reiterated in the sporadic form. In fact no genetic factors have been unequivocally associated with increased risk for sporadic PD. The difficulty in identifying susceptibility factors in PD has not only been because of numerous underpowered studies, but we have been unable to dissect out the genetic component in a multifactorial disease. This review aims to summarize the genetic findings within PD.
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Review Article| September 23 2005
Molecular genetic pathways in Parkinson's disease: a review
Shushant Jain ;
*Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, U.K.
†National Institute of Ageing, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892, U.S.A.
‡Reta Lila Weston Institute of Neurological Sciences, Windeyer Building, University College London, 46 Cleveland Street, London W1T 4JF, U.K.
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Nicholas W. Wood ;
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Shushant Jain, Nicholas W. Wood, Daniel G. Healy; Molecular genetic pathways in Parkinson's disease: a review. Clin Sci (Lond) 1 October 2005; 109 (4): 355–364. doi: https://doi.org/10.1042/CS20050106
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