OSA (obstructive sleep apnoea) is a common condition that is strongly associated with cardiovascular disease. It is remains unclear what role OSA plays in determining cardiovascular risk. The immediate physiological changes that occur during upper airway obstruction are potential contributors to cardiovascular risk in OSA. These changes include increased sympathetic activity, which is responsive to treatment of OSA with CPAP (continuous positive airway pressure). In this issue of Clinical Science, the possible role of a common polymorphism in the β1-adrenoreceptor [R389G (Arg389Gly)] has been investigated by Börgel and co-workers. Measurements of heart rate and blood pressure in untreated OSA patients were not related to the R389G polymorphism. There were changes in heart rate and diastolic blood pressure with CPAP treatment that were related to this polymorphism. Reduction in heart rate with CPAP treatment was associated with the R389R genotype. By contrast, a reduction in diastolic blood pressure was associated with the Gly389 carriers. These findings are intriguing, but difficult to fully explain. Further study is needed to determine if there is an important role of the R389G polymorphism in modifying cardiovascular responses among OSA patients.
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January 2006
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Commentary|
December 12 2005
What role do adrenoreceptor polymorphisms play in modifying cardiovascular responses in obstructive sleep apnoea?
Nigel Mcardle
1University Department of Medicine, Royal Perth Hospital, Wellington Street, Perth, WA 6000, Australia
Correspondence: Dr Nigel McArdle (email [email protected]).
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Publisher: Portland Press Ltd
Received:
September 29 2005
Accepted:
November 16 2005
Accepted Manuscript online:
November 16 2005
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2006
Clin Sci (Lond) (2006) 110 (1): 89–91.
Article history
Received:
September 29 2005
Accepted:
November 16 2005
Accepted Manuscript online:
November 16 2005
Citation
Nigel Mcardle; What role do adrenoreceptor polymorphisms play in modifying cardiovascular responses in obstructive sleep apnoea?. Clin Sci (Lond) 1 January 2006; 110 (1): 89–91. doi: https://doi.org/10.1042/CS20050295
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