Endothelin and reactive oxygen species have been identified as important mediators in the pathogenesis of hypertension and associated end-organ damage. In the present issue of Clinical Science, Callera and co-workers have provided new evidence that endothelin stimulates mitochondria to generate reactive oxygen species in the vascular wall during mineralocorticoid-induced hypertension in the rat. These studies open a new line of investigation that could be important for the development of therapeutic strategies; however, there still remains a great deal of uncertainty about the mechanisms that define the relationship between endothelin and oxidative stress in hypertension.
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Commentary| January 17 2006
How does endothelin induce vascular oxidative stress in mineralocorticoid hypertension?
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David M. Pollock; How does endothelin induce vascular oxidative stress in mineralocorticoid hypertension?. Clin Sci (Lond) 1 February 2006; 110 (2): 205–206. doi: https://doi.org/10.1042/CS20050359
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