Apoptosis, programmed cell death, of neutrophil and eosinophil granulocytes is a potential control point in the physiological resolution of innate immune responses. There is also increasing evidence that cellular processes of apoptosis can be dysregulated by pathogens as a mechanism of immune evasion and that delayed apoptosis, resulting in prolonged inflammatory cell survival, is important in persistence of tissue inflammation. The identification of cell-type specific pathways to apoptosis may allow the design of novel anti-inflammatory therapies or agents to augment the innate immune responses to infection. This review will explore the physiological roles of granulocyte apoptosis and their importance in infectious and non-infectious lung disease.
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March 2006
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Review Article|
February 10 2006
Granulocyte apoptosis in the pathogenesis and resolution of lung disease
Stephen M. Bianchi;
Stephen M. Bianchi
*Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, U.K.
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David H. Dockrell;
David H. Dockrell
†Academic Unit of Infectious Diseases, Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, U.K.
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Stephen A. Renshaw;
Stephen A. Renshaw
*Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, U.K.
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Ian Sabroe;
Ian Sabroe
*Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, U.K.
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Moira K. B. Whyte
*Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, M Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, U.K.
Correspondence: Professor Moira K. B. Whyte (email [email protected]).
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Publisher: Portland Press Ltd
Received:
June 08 2005
Revision Received:
September 01 2005
Accepted:
September 19 2005
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2006
Clin Sci (Lond) (2006) 110 (3): 293–304.
Article history
Received:
June 08 2005
Revision Received:
September 01 2005
Accepted:
September 19 2005
Citation
Stephen M. Bianchi, David H. Dockrell, Stephen A. Renshaw, Ian Sabroe, Moira K. B. Whyte; Granulocyte apoptosis in the pathogenesis and resolution of lung disease. Clin Sci (Lond) 1 March 2006; 110 (3): 293–304. doi: https://doi.org/10.1042/CS20050178
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