There is a considerable body of evidence gathered from studies over the past half a century indicating that a high level of physical activity and a moderately high or high degree of cardiorespiratory fitness reduces the risk of CVD (cardiovascular disease). Recent data suggest that high levels of physical activity or fitness may be particularly beneficial to individuals with insulin-resistant conditions, such as the metabolic syndrome, Type II diabetes or obesity. These individuals, if unfit and sedentary, exhibit increased CVD risk, but their dose–response relationship for physical activity/fitness appears to be particularly steep such that, when they undertake high levels of activity (or have high fitness), their level of risk becomes closer to that of their normal weight or nondiabetic peers. This may be due to effects of physical activity in normalizing the metabolic dysfunction particularly associated with insulin-resistant conditions.
Skip Nav Destination
Article navigation
April 2006
-
Cover Image
Cover Image
- PDF Icon PDF LinkTable of Contents
Review Article|
March 15 2006
Physical activity, fitness and cardiovascular disease risk in adults: interactions with insulin resistance and obesity
Jason M. R. Gill;
*Institute of Diet, Exercise and Lifestyle (IDEAL), Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, U.K.
Correspondence: Dr Jason M. R. Gill (email [email protected]).
Search for other works by this author on:
Dalia Malkova
Dalia Malkova
*Institute of Diet, Exercise and Lifestyle (IDEAL), Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, U.K.
†Division of Developmental Medicine, University of Glasgow, Yorkhill Hospitals, Glasgow G3 8SJ, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
July 05 2005
Revision Received:
November 17 2005
Accepted:
November 21 2005
Accepted Manuscript online:
March 15 2006
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2006
Clin Sci (Lond) (2006) 110 (4): 409–425.
Article history
Received:
July 05 2005
Revision Received:
November 17 2005
Accepted:
November 21 2005
Accepted Manuscript online:
March 15 2006
Citation
Jason M. R. Gill, Dalia Malkova; Physical activity, fitness and cardiovascular disease risk in adults: interactions with insulin resistance and obesity. Clin Sci (Lond) 1 April 2006; 110 (4): 409–425. doi: https://doi.org/10.1042/CS20050207
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |