Tyrosine kinases play key roles in cell proliferation, survival and differentiation. Their aberrant activation, caused either by the formation of fusion genes by chromosome translocation or by intragenic changes, such as point mutations or internal duplications, is of major importance in the development of many haematological malignancies. An understanding of the mechanisms by which BCR-ABL contributes to the pathogenesis of chronic myeloid leukaemia led to the development of imatinib, the first of several tyrosine kinase inhibitors to enter clinical trials. Although the development of resistance has been problematic, particularly in aggressive disease, the development of novel inhibitors and combination with other forms of therapy shows promise.
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October 2006
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Review Article|
September 13 2006
Signal transduction therapy in haematological malignancies: identification and targeting of tyrosine kinases
Andrew Chase;
Andrew Chase
1Wessex Regional Genetics Laboratory, Salisbury and Human Genetics Division, University of Southampton, Salisbury District Hospital, Salisbury SP2 8BJ, U.K.
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Nicholas C. P. Cross
1Wessex Regional Genetics Laboratory, Salisbury and Human Genetics Division, University of Southampton, Salisbury District Hospital, Salisbury SP2 8BJ, U.K.
Correspondence: Professor Nicholas C. P. Cross (email ncpc@soton.ac.uk).
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Clin Sci (Lond) (2006) 111 (4): 233–249.
Article history
Received:
February 10 2006
Revision Received:
March 31 2006
Accepted:
April 03 2006
Citation
Andrew Chase, Nicholas C. P. Cross; Signal transduction therapy in haematological malignancies: identification and targeting of tyrosine kinases. Clin Sci (Lond) 1 October 2006; 111 (4): 233–249. doi: https://doi.org/10.1042/CS20060035
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