Expansion of the capillary network, or angiogenesis, occurs following endurance training. This process, which is reliant on the presence of VEGF (vascular endothelial growth factor), is an adaptation to a chronic mismatch between oxygen demand and supply. Patients with IC (intermittent claudication) experience pain during exercise associated with an inadequate oxygen delivery to the muscles. Therefore the aims of the present study were to examine the plasma VEGF response to acute exercise, and to establish whether exercise training alters this response in patients with IC. In Part A, blood was collected from patients with IC (n=18) before and after (+20 and +60 min post-exercise) a maximal walking test to determine the plasma VEGF response to acute exercise. VEGF was present in the plasma of patients (45.11±29.96 pg/ml) and was unchanged in response to acute exercise. Part B was a training study to determine whether exercise training altered the VEGF response to acute exercise. Patients were randomly assigned to a treatment group (TMT; n=7) that completed 6 weeks of high-intensity treadmill training, or to a control group (CON; n=6). All patients completed a maximal walking test before and after the intervention, with blood samples drawn as for Part A. Training had no effect on plasma VEGF at rest or in response to acute exercise, despite a significant increase in maximal walking time in the TMT group (915±533 to 1206±500 s; P=0.009) following the intervention. The absence of a change in plasma VEGF may reflect altered VEGF binding at the endothelium, although this cannot be confirmed by the present data.
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December 2006
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Research Article|
November 14 2006
Effect of training on the response of plasma vascular endothelial growth factor to exercise in patients with peripheral arterial disease
Rachel E. Wood;
Rachel E. Wood
*Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
†School of Human Movement Studies, Queensland University of Technology, Kelvin Grove, Queensland, Australia
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Brad E. Sanderson;
Brad E. Sanderson
‡Department of Surgery, University of Queensland, Herston, Queensland, Australia
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Christopher D. Askew;
Christopher D. Askew
‡Department of Surgery, University of Queensland, Herston, Queensland, Australia
§Faculty of Science, Health, and Education, University of the Sunshine Coast, Maroochydore, Queensland, Australia
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Philip J. Walker;
Philip J. Walker
‡Department of Surgery, University of Queensland, Herston, Queensland, Australia
∥Department of Vascular Surgery, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia
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Simon Green;
Simon Green
¶School of Biological, Biomedical, and Molecular Sciences, University of New England, Armidale, New South Wales, Australia
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Ian B. Stewart
*Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
†School of Human Movement Studies, Queensland University of Technology, Kelvin Grove, Queensland, Australia
Correspondence: Dr Ian Stewart, at Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia (email [email protected]).
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Publisher: Portland Press Ltd
Received:
June 16 2006
Revision Received:
August 04 2006
Accepted:
August 24 2006
Accepted Manuscript online:
August 24 2006
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2006
Clin Sci (Lond) (2006) 111 (6): 401–409.
Article history
Received:
June 16 2006
Revision Received:
August 04 2006
Accepted:
August 24 2006
Accepted Manuscript online:
August 24 2006
Citation
Rachel E. Wood, Brad E. Sanderson, Christopher D. Askew, Philip J. Walker, Simon Green, Ian B. Stewart; Effect of training on the response of plasma vascular endothelial growth factor to exercise in patients with peripheral arterial disease. Clin Sci (Lond) 1 December 2006; 111 (6): 401–409. doi: https://doi.org/10.1042/CS20060151
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